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Sebelipase alfa
go.drugbank.com/drugs/DB11563ApprovedInvestigationalThis lipid accumulation can lead to end-organ damage in the form of liver dysfunction or malabsorption secondary to intestinal dysfunction. … [L39337] Sebelipase alfa is a recombinant form LAL approved for the treatment of LAL deficiency.
Praziquantel
go.drugbank.com/drugs/DB01058ApprovedInvestigationalVet approved[A263201] The efficacy of praziquantel in treating parasitic flatworms infection with low cost (~US$0.20 drug cost to treat a child) makes it an integral to WHO's plan to eliminate schistosomiasis by 2030 … [A263206,A263211] Despite being approved since 1980, the exact mechanism of action is yet to be elucidated.[A263211]
Mixtures: Eqvalan Duo Oral Paste for HorseRiociguat
go.drugbank.com/drugs/DB08931ApprovedInvestigationalRiociguat is marketed under the brand Adempas® by Bayer HealthCare Pharmaceuticals. Treatment with riociguat costs USD $7,500 for 30 days of treatment. … Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for
Categories: Antihypertensives for Pulmonary Arterial HypertensionTemazepam
go.drugbank.com/drugs/DB00231ApprovedIn particular, before temazepam saw regular prescription use in civilians it was - and still is - employed by the US military as a sedative-hypnotic medication to be taken by soldiers, pilots, etc. to … obtain the necessary rest required for medical recovery or scheduled maneuvers and operations [A175339].
Products: Co Temazepam Capsules 15mg, Co Temazepam Capsules 30mgElbasvir
go.drugbank.com/drugs/DB11574Approved[A19593] Substitutions at amino acid positions 28, 30, 31, or 93 are known to confer resistance to elbasvir. … [A19626] In a computational target-based drug repurposing investigation published in April 2020, elbasvir was predicted to bind stably and preferentially to three proteins necessary for viral replication
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseEmtricitabine
go.drugbank.com/drugs/DB00879ApprovedInvestigational[L9019] The drug works by inhibiting HIV reverse transcriptase, preventing transcription of HIV RNA to DNA.[L9019] Emtricitabine was granted FDA approval on 2 July 2003.[L9019] … Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseEstradiol valerate
go.drugbank.com/drugs/DB13956ApprovedInvestigationalVet approveddue to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation … As a pro-drug of estradiol, estradiol acetate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and ERβ subtypes, which are located in
Categories: Hormonal Contraceptives for Systemic UseAdagrasib
go.drugbank.com/drugs/DB15568ApprovedInvestigational[L43847] In December 2022, the FDA granted accelerated approval to adagrasib for the treatment of KRAS<sup>G12C</sup>-mutated locally advanced or metastatic NSCLC who have received at least one prior systemic … [A254941] However, the development of KRAS inhibitors has been challenging due to their high affinity for guanosine triphosphate (GTP) and guanosine diphosphate (GDP), as well as the lack of a clear binding
Eteplirsen
go.drugbank.com/drugs/DB06014ApprovedInvestigationalEteplirsen directly works on the DMD gene to promote dystrophin production. Eteplirsen was the first treatment for DMD approved by the FDA.[A244925] … is amenable to exon 51 skipping.
Categories: Compounds used in a research, industrial, or household settingPhenazopyridine
go.drugbank.com/drugs/DB01438ApprovedInvestigationalIngestion of phenazopyridine is found to change the appearance of the urine by imparting an orange or red color, as it is considered an azo dye.[L7829] … In the USA, this drug was previously marked by Roche but has been discontinued by the FDA.[L7832] It is still used in various parts of the world.