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Carbimazole
go.drugbank.com/drugs/DB00389ApprovedAn imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.
Metharbital
go.drugbank.com/drugs/DB00463ApprovedWithdrawnMetharbital is a barbiturate anticonvulsant, similar to phenobarbital, marketed as Gemonil by Abbott Laboratories. It was patented in 1905 by Emil Fischer of Merck.
Promethazine
go.drugbank.com/drugs/DB01069ApprovedInvestigational[A189901] Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting. … Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946.
Relacorilant
go.drugbank.com/drugs/DB14976ApprovedInvestigationalOriginally investigated to manage the metabolic and endocrinologic complications of hypercortisolism, such as Cushing’s syndrome, its clinical utility has pivoted toward oncology as a potent sensitizing … Relacorilant is a first-in-class, selective glucocorticoid receptor antagonist.
Mangafodipir
go.drugbank.com/drugs/DB06796ApprovedInvestigationalWithdrawnMangafodipir is a contrast agent used as a diagnostic tool administered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver and pancreas. … The contrast agent is present as mangafodipir trisodium marketed under the name Teslascan.
Categories: Compounds used in a research, industrial, or household settingGallium Ga-68 gozetotide
go.drugbank.com/drugs/DB16019ApprovedInvestigational[L27006] It is administered intravenously. … [A225396] Ga-68 PSMA-11 is an imaging agent that binds PSMA during positron emission tomography: it emits positrons to indicate the presence of PSMA-positive prostate cancer lesions in patients with suspected
Categories: Compounds used in a research, industrial, or household settingSynonyms: (68)Ga Labeled Glu-NH-CO-NH-Lys(ahx)-hbed-CC, Gallium Ga 68-labeled psma ligand Glu-urea-Lys(ahx)-hbed-CCPegaspargase
go.drugbank.com/drugs/DB00059ApprovedInvestigationalPegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia … [A103,A255912,L44667] Pegaspargase has the same mechanism of action as [L-asparaginase] derived from _Escherichia coli_, a previously developed enzyme used for the treatment of acute lymphoblastic
Categories: Compounds used in a research, industrial, or household settingEzogabine
go.drugbank.com/drugs/DB04953ApprovedWithdrawnIt is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures … Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine.
Milrinone
go.drugbank.com/drugs/DB00235ApprovedInvestigational[A228338, A11759, A228323, A228333, A228348, L31483] Milrinone was originally synthesized at the Sterling Winthrop Research Institute in the 1980s. … [A228333] As a PDE-III inhibitor, milrinone results in increased cAMP levels and improves cardiac function and peripheral vasodilation in acute decongested heart failure.
Categories: Compounds used in a research, industrial, or household settingAcenocoumarol
go.drugbank.com/drugs/DB01418ApprovedInvestigationalAcenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index