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Displaying results 2011 - 2020 of 3180 in total
  1. Drug

    Nebivolol

    go.drugbank.com/drugs/DB04861
    ApprovedInvestigational

    Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and di...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: CORETEL-N
  2. Drug

    Elacridar

    go.drugbank.com/drugs/DB04881
    Investigational

    Elacridar (GW120918) is an oral bioenhancer that targets multiple drug resistance in tumors. In many cases, the appearance of multidrug resistance in cancer is due to a change in expression of protein inhibitors. As of August 2007 elacri...

    Categories: P-glycoprotein inhibitors
  3. Drug

    Dapoxetine

    go.drugbank.com/drugs/DB04884
    Investigational

    Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latenc...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors
  4. Drug

    Vapreotide

    go.drugbank.com/drugs/DB04894
    Investigational

    Vapreotide is a synthetic octapeptide somatostatin analog. It was being studied for the treatment of cancer.

    Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors
  5. Drug

    Tesmilifene

    go.drugbank.com/drugs/DB04905
    Investigational

    Tesmilifene is a novel potentiator of chemotherapy which, when added to doxorubicin, achieved an unexpected and very large survival advantage over doxorubicin alone in a randomized trial in advanced breast cancer.

    Synonyms: N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamineCategories: P-glycoprotein inducers, P-glycoprotein inhibitors
  6. Drug

    Elafibranor

    go.drugbank.com/drugs/DB05187
    ApprovedInvestigational

    Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR) α and β/δ agonist that works to inhibit bile acid synthesis. On June 10, 2024, elafibranor was granted accelerated approval by the FDA for the treatment of primary b...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers
  7. Drug

    N,N-dimethylglycine

    go.drugbank.com/drugs/DB02083
    Experimental

    Synonyms: N,N-dimethylglycine, N,N-Dimethylaminoacetic acidCategories: N-substituted Glycines
  8. Drug

    nor-NOHA

    go.drugbank.com/drugs/DB02381
    Investigational

    N-Hydroxy-nor-L-arginine (nor-NOHA) is under investigation in clinical trial NCT02009527 (Arginase Inhibition in Ischemia-reperfusion Injury).

    Synonyms: N-hydroxy-nor-arginine, N-hydroxy-nor-L-arginine
  9. Drug

    Cholic Acid

    go.drugbank.com/drugs/DB02659
    ApprovedInvestigational

    A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. [PubChem] Cholic acid, formulated as Cholbam capsules, is approved by the United Sta...

    Categories: P-glycoprotein inducers
  10. Drug

    Glycocholic acid

    go.drugbank.com/drugs/DB02691
    Investigational

    The glycine conjugate of cholic acid. It acts as a detergent to solubilize fats for absorption and is itself absorbed.

    Synonyms: N-choloylglycineCategories: N-substituted Glycines