Search
Telaprevir
go.drugbank.com/drugs/DB05521ApprovedWithdrawnTelaprevir was available as a fixed dose product (tradename Incivek) used for the treatment of chronic Hepatitis C. … The barrier for develoment of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors, another class of DAAs [A19593].
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseFomivirsen
go.drugbank.com/drugs/DB06759ApprovedWithdrawnFomivirsen is marketed under the trade name Vitravene for intravitreal injection and was the first antisense drug to be approved by the Food and Drug Administration (FDA). … The drug was withdrawn by the FDA because while there was a high unmet need for drugs to treat CMV when the drug was initially discovered and developed due to the CMV arising in people with AIDS, the development
Ciclopirox
go.drugbank.com/drugs/DB01188ApprovedInvestigationalCiclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses.
Categories: Antifungals for Topical Use, Antifungals for Dermatological UseIstradefylline
go.drugbank.com/drugs/DB11757ApprovedInvestigationalIstradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. … [A184067] Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A<sub>2A</sub> receptors in the basal ganglia.
Categories: Adenosine A2 Receptor Antagonists, Purinergic P1 Receptor AntagonistsFlunisolide
go.drugbank.com/drugs/DB00180ApprovedIt is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors.
Categories: Corticosteroids for Systemic Use, Drugs for Obstructive Airway DiseasesLoracarbef
go.drugbank.com/drugs/DB00447ApprovedWithdrawnLoracarbef is a carbacephem antibiotic sometimes grouped together with the second-generation cephalosporin antibiotics. It is marketed under the trade name Lorabid.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseDelavirdine
go.drugbank.com/drugs/DB00705ApprovedInvestigationalWithdrawnA potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseRolitetracycline
go.drugbank.com/drugs/DB01301ApprovedWithdrawnA pyrrolidinylmethyl tetracycline.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseFidanacogene elaparvovec
go.drugbank.com/drugs/DB16783ApprovedInvestigationalfrom week 12 to month 15 compared to an ABR of 4.43 for the pre-treatment period. … Current available treatments include substitution therapy involving the intravenous administration of standard factor IX once a week for bleeding or as prophylaxis and 2–3 times a week for severe hemophilia
Dabrafenib
go.drugbank.com/drugs/DB08912ApprovedInvestigationalIt was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation.[L41955] It was also used for metastatic non-small cell lung cancer with the same mutation.