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Displaying results 2051 - 2060 of 10000 in total
  1. Drug

    Elinzanetant

    go.drugbank.com/drugs/DB18968
    ApprovedInvestigational

    Elinzanetant is a non-hormonal, selective, dual neurokinin 1 (NK-1) and 3 (NK-3) receptor antagonist. … [L53798] By blocking receptor signaling on kisspeptin/neurokinin B/dynorphin (KNDy) neurons, which are hyperactivated due to estrogen decline in menopause, elinzanetant modulates neuronal activity involved

    Categories: Substance P/Neurokinin-1 Receptor Antagonist, Neurokinin 1 AntagonistsSynonyms: Benzamide, 3-(5-methyl-2-tbenzeneacetamide, n-(4-(4-fluoro-2-methylphenyl)-6-((7s,9as)-hexahydro-7-(hydroxymethyl)pyrazino(2,1-c)(1,4)oxazin-8(1h)-yl)-3-pyridinyl)-n,.alpha.,.alpha., 2-(3,5-bis(trifluoromethyl)phenyl)-n-(4-(4-fluoro-2-methylphenyl)-6-((7s,9as)-7-(hydroxymethyl)hexahydropyrazino(2,1-c)(1,4)oxazin-8(1h)-yl)-3-pyridinyl)-n,2-dimethylpropanamide
  2. Drug

    Mosliciguat

    go.drugbank.com/drugs/DB19425
    Investigational

    Mosliciguat is under investigation in clinical trial NCT06635850 (A Phase 2 Study of Mosliciguat in PH-ILD).

    Synonyms: (5s)-5-((2-(4-carboxyphenyl)ethyl)(2-(2-((3-chloro-4'-(trifluoromethyl)biphenyl-4-yl)methoxy)phenyl)ethyl)amino)-5,6,7,8-tetrahydroquinoline-2-carboxylic acid, 2-quinolinecarboxylic acid, 5-((2-(4-carboxyphenyl)ethyl)(2-(2-((3-chloro-4'-(trifluoromethyl)(1,1'-biphenyl)-4-yl)methoxy)phenyl)ethyl)amino)-5,6,7,8-tetrahydro-, (5s)-
  3. Drug

    AGI-134

    go.drugbank.com/drugs/DB19005
    Investigational

    AGI-134 is under investigation in clinical trial NCT03593226 (Study to Evaluate Safety & Tolerability of AGI-134 in Solid Tumour).

    Synonyms: 2R)-1-((2-(5-((3-(((2R,3R,4R,5S,6R)-5-(((2S,3R,4S,5S,6R)-3,5-DIHYDROXY-6-(HYDROXYMETHYL)-4-(((2R,3R,4S,5R,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL)OXY)OXAN-2-YL)OXY)-3-ACETAMIDO-4-HYDROXY-6-(HYDROXYMETHYL, )OXAN-2-YL)OXY)PROPYL)CARBAMOYL) PENTANAMI
  4. Drug

    OBI-3424

    go.drugbank.com/drugs/DB16057
    Investigational

    OBI-3424 is under investigation in clinical trial NCT04315324 (Study to Test Akr1c3-activated Prodrug OBI-3424 (OBI-3424) in Patients With Relapsed/refractory T-cell Acute Lymphoblastic Leukemia (T-ALL

    Synonyms: 3-(5-((1R)-1-(Bis(aziridin-1-yl(phosphoryloxy)ethyl)-2-nitrophenoxy)-N,N-dimethylbenzamide, 3-[5-[(1R)-1-[bis(aziridin-1-yl(phosphoryloxy]ethyl]-2-nitrophenoxy]-N,N-dimethylbenzamide
  5. Drug

    BMS-986278

    go.drugbank.com/drugs/DB18011
    Investigational

    Synonyms: (1s,3s)-3-((2-methyl-6-(1-methyl-5-(((methyl(propyl)carbamoyl)oxy)methyl)-1h-1,2,3-triazol-4-yl)pyridin-3-yl)oxy)cyclohexane-1-carboxylic acid, Cyclohexanecarboxylic acid, 3-((2-methyl-6-(1-methyl-5-((((methylpropylamino)carbonyl)oxy)methyl)-1h-1,2,3-triazol-4-yl)-3-pyridinyl)oxy)-, (1s,3s)-
  6. Drug

    1-(3-fluoro-4-(7-(5-methyl-1H-imidazol-2-yl)-1-oxo-2,3-dihydro-1H-isoindo-1-4-yl)-phenyl)-3-(3-trifluoromethyl-phenyl)-urea

    go.drugbank.com/drugs/DB18632
    Experimental

    Synonyms: Urea, n-(4-(2,3-dihydro-7-(5-methyl-1h-imidazol-2-yl)-1-oxo-1h-isoindol-4-yl)-3-fluorophenyl)-n'-(3-(trifluoromethyl)phenyl), 1-(3-fluoro-4-(7-(5-methyl-1H-imidazol-2-yl)-1-oxo-2,3-dihydro-1H-isoindo-1-4-yl)-phenyl)-3-(3-trifluoromethyl-phenyl)-urea
  7. Drug

    Zemirciclib

    go.drugbank.com/drugs/DB18823
    Investigational

    Synonyms: (1s,3r)-3-(acetylamino)-n-(5-chloro-4-(5,6-dihydro-5,5-dimethyl-4h-pyrrolo(1,2-b)pyrazol-3-yl)-2-pyridinyl)cyclohexanecarboxamide
  8. Drug

    3-(5-Amino-7-oxo-3,7-dihydro-2H-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(2-{[2-(hydroxymethyl)phenyl]sulfanyl}benzyl)benzamide

    go.drugbank.com/drugs/DB03231
    Experimental

    Synonyms: 3-(5-Amino-7-oxo-3,7-dihydro-2H-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(2-{[2-(hydroxymethyl)phenyl]sulfanyl}benzyl)benzamide
  9. Drug

    2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol

    go.drugbank.com/drugs/DB07982
    Experimental

    Synonyms: 2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol
  10. Drug

    1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea

    go.drugbank.com/drugs/DB07362
    Experimental

    Synonyms: 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea