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Nalmefene
go.drugbank.com/drugs/DB06230ApprovedInvestigationalWithdrawn[L1024] Nalmefene was approved in the United States in 1995 as an antidote for opioid overdose.[A245839] Nalmefene injection is used to manage known or suspected opioid overdose. … It is used for complete or partial reversal of opioid drug effects, including respiratory depression, induced by either natural or synthetic opioids.
Categories: Drugs Used in Alcohol Dependence, Drugs Used in Addictive DisordersClove oil
go.drugbank.com/drugs/DB11338ApprovedNutraceuticalThe FDA categorizes clove oil as generally recognized as safe (GRAS) for use in dental cement or as a food additive [F108]. … Clove is native of Indonesia but is now cultured in several parts of the world, including Brazil in the state of _Bahia_.
Talc
go.drugbank.com/drugs/DB09511ApprovedInvestigationalAlthough talc has been widely used for decades, lawsuits that have come to the surface claim serious health complications linked to its use. … It is a substance often found in cosmetic and personal hygiene products including baby powder, adult body powders and facial powders.
Mixtures: OHUI Sun Science Sun Block EX plus Beige, Face It Hd Perfect Bb Spf30 Pa 02Categories: Compounds used in a research, industrial, or household settingCryptenamine
go.drugbank.com/drugs/DB00785ApprovedCryptenamine has a marked and re-producible depressor effect when given intravenously to hypertensive patients, however the mechanism of action is not known. … It has been used in the treatment of hypertension but has largely been replaced by drugs with fewer adverse effects.
Categories: Heterocyclic Compounds with 4 or More RingsTamoxifen
go.drugbank.com/drugs/DB00675ApprovedInvestigational[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments. … [L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with [anastrozole].
Synonyms: (Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine, (Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamineAndexanet alfa
go.drugbank.com/drugs/DB14562ApprovedIt is marketed as Andexxa for intravenous injection or infusion and is indicated for the reversal of anticoagulation in combination with [rivaroxaban] and [apixaban] in cases of life-threatening or uncontrolled … Andexanet alfa retains the structural similarity to that of endogenous human factor Xa, but exists in its mature functional form without the need for activation via the intrinsic or extrinsic coagulation
Categories: Factor XSynonyms: r-AntidoteTenofovir alafenamide
go.drugbank.com/drugs/DB09299ApprovedInvestigational[T239] Tenofovir alafenamide is an alanine ester form characterized for presenting low systemic levels but high intracellular concentration. … Tenofovir alafenamide is a novel [tenofovir] prodrug developed in order to improve renal safety when compared to the counterpart [tenofovir disoproxil].
Categories: Antivirals used in combination for the treatment of HIV infections, Antivirals for Systemic UseAlpelisib
go.drugbank.com/drugs/DB12015ApprovedInvestigationalnegative, PIK3CA-mutated, advanced or metastatic breast cancer in combination with [fulvestrant] for postmenopausal women and male patients. … To initiate alpelisib therapy, it is required that the presence of a PIK3CA mutation in the tissue and/or liquid biopsy sample collection should be confirmed via FDA-approved diagnostic tests.
Categories: Class I Phosphatidylinositol 3-Kinases, antagonists & inhibitorsTemazepam
go.drugbank.com/drugs/DB00231ApprovedIn particular, before temazepam saw regular prescription use in civilians it was - and still is - employed by the US military as a sedative-hypnotic medication to be taken by soldiers, pilots, etc. to … and approved later on.
Products: Co Temazepam Capsules 15mg, Co Temazepam Capsules 30mgZenocutuzumab
go.drugbank.com/drugs/DB15559ApprovedInvestigational[L51983] In May 2026, zenocutuzumab was granted additional approval by the US FDA for use in NRG1-positive cholangiocarcinoma. … [A264833] On December 4, 2024, the FDA granted accelerated approval to zenocutuzumab for the treatment of non-small cell lung cancer and pancreatic adenocarcinoma.