Talc

Identification

Summary

Talc is a mineral used to prevent recurrence of malignant pleural effusions in symptomatic patients during thoracoscopy or open thoracotomy.

Brand Names
Sclerosol
Generic Name
Talc
DrugBank Accession Number
DB09511
Background

Talc is a mineral composed primarily of magnesium, silicon and oxygen. It is a substance often found in cosmetic and personal hygiene products including baby powder, adult body powders and facial powders. Talc helps absorb moisture, freshen materials, and reduce friction to prevent rashes.

Although talc has been widely used for decades, lawsuits that have come to the surface claim serious health complications linked to its use. In fact, recent studies have reported that talc increases the risk of ovarian and endometrial cancers by approximately 30 percent.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 379.259
Monoisotopic: 377.81745674
Chemical Formula
H2Mg3O12Si4
Synonyms
  • Talc
  • Talco
  • Talcum

Pharmacology

Indication

Indicated to prevent recurrence of malignant pleural effusions in symptomatic patients during thoracoscopy or open thoracotomy.

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action

It has very good absorptive properties.

Absorption

Intended for local use only.

Volume of distribution

Intended for local use only.

Protein binding

Intended for local use only.

Metabolism

Intended for local use only.

Route of elimination

Intended for local use only.

Half-life

Intended for local use only.

Clearance

Intended for local use only.

Adverse Effects
Medicalerrors
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Toxicity

LC50: Not available.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AlfacalcidolThe serum concentration of Talc can be increased when it is combined with Alfacalcidol.
CalcifediolThe serum concentration of Talc can be increased when it is combined with Calcifediol.
CalcitriolThe serum concentration of Talc can be increased when it is combined with Calcitriol.
CholecalciferolThe serum concentration of Talc can be increased when it is combined with Cholecalciferol.
CinoxacinTalc can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
CiprofloxacinTalc can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
DeferiproneTalc can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy.
DelafloxacinTalc can cause a decrease in the absorption of Delafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
DihydrotachysterolThe serum concentration of Talc can be increased when it is combined with Dihydrotachysterol.
DoxercalciferolThe serum concentration of Talc can be increased when it is combined with Doxercalciferol.
Interactions
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Food Interactions
No interactions found.

Products

Products
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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
SclerosolAerosol, powder4 g/25.0gIntrapleuralBryan Corporation2013-06-30Not applicableUS flag
Sterile TalcPowder5 g/100mLIntrapleuralBryan Corporation2003-12-15Not applicableUS flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
BabyPowder100 g/100gTopicalWalgreen Company2014-07-17Not applicableUS flag
Budpak BabyPowder0.9 g/1gTopicalBudpak Inc.2014-07-072015-12-18US flag
Dusting PowderPowder99 g/100gTopicalViny Health and Beauty Products Inc2012-02-012017-10-26US flag
Health Smart BabyPowder1 g/1gTopicalHome Smart Products2012-12-19Not applicableUS flag
Natures Choice BabyPowder99 g/100gTopicalUnipack2016-06-07Not applicableUS flag
Pan Aromas BabyPowder1 g/1gTopicalPan Aromas Llc2012-12-19Not applicableUS flag
Sof Skin Baby PowderPowder1 g/1gTopicalViny Health and Beauty Products Inc2007-03-272017-10-17US flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
AHC Premium Intense Contour BalmTalc (2.05 g/50mL) + Adenosine (0.02 g/50mL) + Aluminium tristearate (0.04 g/50mL) + Aluminum hydroxide (0.45 g/50mL) + Arbutin (1 g/50mL) + Methicone (20 CST) (1.3 g/50mL) + Octinoxate (1.5 g/50mL) + Titanium dioxide (3.96 g/50mL) + Zinc oxide (0.96 g/50mL)CreamTopicalCarver Korea Co.,Ltd.2014-01-152017-11-22US flag
CaldeseneTalc (57.51 g/71g) + Zinc oxide (10.65 g/71g)PowderTopicalInsight Pharmaceuticals2009-07-092017-08-31US flag
Careline Perfect Care BBTalc (2.5 g/100g) + Allantoin (0.2 g/100g) + Caffeine (0.2 g/100g) + Octinoxate (4 g/100g) + Titanium dioxide (5 g/100g)CreamTopicalCosmopharm Ltd.2015-09-172019-09-01US flag
Careline Perfect Care BBTalc (2.5 g/100g) + Allantoin (0.2 g/100g) + Caffeine (0.2 g/100g) + Octinoxate (4 g/100g) + Titanium dioxide (2.5 g/100g)CreamTopicalCosmopharm Ltd.2015-09-172019-09-01US flag
Face It Hd Perfect Bb Spf30 Pa 01Talc (0.684 mL/100mL) + Betaine (2 mL/100mL) + Octinoxate (6 mL/100mL) + Titanium dioxide (6.36 mL/100mL) + Zinc oxide (2.88 mL/100mL)CreamTopicalThefaceshop Co., Ltd.2011-08-23Not applicableUS flag
Face It Hd Perfect Bb Spf30 Pa 02Talc (0.684 mL/100mL) + Betaine (2 mL/100mL) + Octinoxate (6 mL/100mL) + Titanium dioxide (6.36 mL/100mL) + Zinc oxide (2.88 mL/100mL)CreamTopicalThefaceshop Co., Ltd.2011-08-23Not applicableUS flag
Foot and Body PowderTalc (90.8 kg / 91.7 kg) + Zinc undecylenate (908 g / 91.7 kg)PowderTopicalMueller Sports Medicine, Inc.1970-12-312003-08-01Canada flag
Foot Spray With PowderTalc (18 %) + Undecylenic acid (.35 %)AerosolTopicalMueller Sports Medicine, Inc.1970-12-312003-08-01Canada flag
Fresh Scent Protective PowderTalc (115 g/142g) + Zinc oxide (21.3 g/142g)PowderTopicalCVS2017-01-112018-04-04US flag
Fresh Scent Protective PowderTalc (115 g/142g) + Zinc oxide (21.3 g/142g)PowderTopicalDavion, Inc.2016-09-012018-04-04US flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
AHC Premium Intense Contour BalmTalc (2.05 g/50mL) + Adenosine (0.02 g/50mL) + Aluminium tristearate (0.04 g/50mL) + Aluminum hydroxide (0.45 g/50mL) + Arbutin (1 g/50mL) + Methicone (20 CST) (1.3 g/50mL) + Octinoxate (1.5 g/50mL) + Titanium dioxide (3.96 g/50mL) + Zinc oxide (0.96 g/50mL)CreamTopicalCarver Korea Co.,Ltd.2014-01-152017-11-22US flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
7SEV7J4R1U
CAS number
14807-96-6
InChI Key
JACYTZHPXAPJCY-UHFFFAOYSA-L
InChI
InChI=1S/3Mg.2H2O.10O.4Si/h;;;2*1H2;;;;;;;;;;;;;;/q3*+2;;;10*-2;4*+4/p-2
IUPAC Name
tetrasilicon(4+) trimagnesium(2+) dihydroxide decaoxidandiide
SMILES
[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[Mg++].[Mg++].[Mg++].[Si+4].[Si+4].[Si+4].[Si+4].[O-][H].[O-][H]

References

General References
  1. MSDS [Link]
  2. product info [Link]
KEGG Drug
D01084
PubChem Substance
347910456
ChemSpider
58828296
RxNav
10323
Wikipedia
Talc

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Not Yet RecruitingTreatmentPleural Effusions1
4RecruitingTreatmentMalignant Pleural Effusions1
3CompletedSupportive CareMetastatic Cancers1
3CompletedTreatmentMalignant Pleural Effusions1
3Unknown StatusPreventionFracture Distal Radius1
3Unknown StatusPreventionSyndrome, Metabolic1
2Unknown StatusTreatmentOsteoarthritis in the Hip Joint / Osteoarthritis of the Knee1
1Active Not RecruitingTreatmentNon-Small Cell Lung Carcinoma (NSCLC)1
1, 2Enrolling by InvitationTreatmentSecondary Pneumothorax1
Not AvailableCompletedNot AvailablePleuritis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
PowderTopical100 g/100g
PowderTopical0.9 g/1g
CreamTopical
AerosolTopical
PowderTopical1 g/1g
PowderTopical99 g/100g
PowderTopical
Aerosol, powderIntrapleural4 g/25.0g
PowderIntrapleural5 g/100mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.65ChemAxon
pKa (Strongest Acidic)15.7ChemAxon
pKa (Strongest Basic)-1.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity13.91 m3·mol-1ChemAxon
Polarizability1.19 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on November 30, 2015 19:10 / Updated on February 21, 2021 18:52