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Levosimendan
go.drugbank.com/drugs/DB00922ApprovedInvestigationalWithdrawnLevosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels.
Categories: Heterocyclic Compounds, 1-Ring, Phosphodiesterase 3 InhibitorsProducts: SIMDAX 2.5 MG/ML KONSANTRE INF.COZ.5 ML X FLAKON, 1 ADET, DAXIM® 2.5 MG / MLMibefradil
go.drugbank.com/drugs/DB01388ApprovedWithdrawnMibefradil was withdrawn from the market in 1998 because of potentially harmful interactions with other drugs.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesEtifoxine
go.drugbank.com/drugs/DB08986ApprovedWithdrawnEtifoxine has been associated with acute liver injury. … It does not bind to the benzodiazepine receptor though the effects are similar to that of benzodiazepines. It is more effective than lorazepam as an anxiolytic, and has fewer side effects.
Categories: Heterocyclic Compounds, 1-RingProducts: EXSIST® CAPSULASCapivasertib
go.drugbank.com/drugs/DB12218ApprovedInvestigationalbrand name TRUQAP, was approved by the FDA for the treatment of adult patients HR-positive, HER2-negative locally advanced or metastatic breast cancer with one or more alterations in PIK3CA/AKT1/PTEN gene … Therefore, significant research has been put into developing genetically targeted treatments.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsLinaclotide
go.drugbank.com/drugs/DB08890ApprovedInvestigationalLinaclotide is a synthetic 14-amino acid cyclic peptide [A260271] and first-in-class guanylate cyclase-C (G-CC) agonist. … [A260276] It is also a homolog of a heat-stable enterotoxin derived from _Escherichia coli_, the first natural ligand that activates GC-C.
Synonyms: -GLUTAMYL-L-TYROSYL-L-CYSTEINYL-L-CYSTEINYL-L-ASPARAGINYL-L-PROLYL-L-ALANYL-L-CYSTEINYL-L-THREONYLGLYCYL-L-CYSTEINYL-, CYCLIC (1->6),(2->10),(5->13)-TRIS(DISULFIDE), L-TYROSINE, L-CYSTEINYL-L-CYSTEINYL-L-.ALPHA.Categories: Guanylate Cyclase-C Agonist, Guanylyl Cyclase C AgonistsLenalidomide
go.drugbank.com/drugs/DB00480ApprovedInvestigational[A228553] It is a 4-amino-glutamyl analogue of [thalidomide] [A228543] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. … [A714, A228543] Thalidomide and its analogues, including lenalidomide, are referred to as immunomodulatory imide drugs (also known as cereblon modulators), which are a class of immunomodulatory drugs that
Synonyms: 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dioneCategories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingDexamethasone acetate
go.drugbank.com/drugs/DB14649ApprovedInvestigationalVet approved[L10701] Recently, dexamethasone has been a drug of interest in the treatment of COVID-19. … [A188724] Dexamethasone acetate has largely been replaced by [dexamethasone] phosphate and continues to be administered for a large variety of inflammatory conditions.
Mixtures: BAYCUTEN® N CREMA, BAYCUTEN® N CREMACategories: P-glycoprotein inducers, P-glycoprotein inhibitorsClonazepam
go.drugbank.com/drugs/DB01068ApprovedIllicitInvestigational[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder. … Unfortunately, however, like most benzodiazepines, clonazepam use has also been associated with recreational use and drug abuse.[FDA Label][L5572,F3763,F3787,F3796]
Synonyms: 5-(2-chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one, 5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-oneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 InhibitorsRotigotine
go.drugbank.com/drugs/DB05271ApprovedInvestigationalRotigotine has been authorized as a treatment for RLS since August 2008. … It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of 24 hours.
Synonyms: (6S)-6-(propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenolCategories: Serotonin 5-HT1 Receptor Agonists, Serotonin Receptor AgonistsNitrofural
go.drugbank.com/drugs/DB00336ApprovedVet approvedWithdrawnNitrofural has also been administered orally in the treatment of trypanosomiasis. … Nitrofural or nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections.
Synonyms: 5-Nitro-2-furaldehyde semicarbazoneMixtures: MADECASSOL C