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Inclisiran
go.drugbank.com/drugs/DB14901ApprovedInvestigationalis a major known risk factor for CVD. … Inclisiran is a long-acting, synthetic small interfering RNA (siRNA) directed against proprotein convertase subtilisin-kexin type 9 (PCSK9), which is a serine protease that regulates plasma low-density
Categories: Compounds used in a research, industrial, or household setting, Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) InhibitorsProducts: LYPTİMZİA 284 MG/1,5 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADETArformoterol
go.drugbank.com/drugs/DB01274ApprovedArformoterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. … Arformoterol inhalation is used to prevent bronchoconstriction in people with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema.
Mixtures: AIRBIR 3/100 MCG INHALASYON IÇIN TOZ IÇEREN KAPSÜL, 120 KPS, AIRBIR 3/100 MCG INHALASYON IÇIN TOZ IÇEREN KAPSÜL, 60 KPSCategories: Cytochrome P-450 Substrates, Adrenergic beta-2 Receptor AgonistsVigabatrin
go.drugbank.com/drugs/DB01080ApprovedInvestigationalAlthough administered as a racemic mixture, only the S(+) enantiomer is pharmacologically active. … [A202124] Its use is now generally reserved for patients who have failed alternative therapies, and its US approval by the FDA in 2009 mandated the creation of a drug registry to monitor patients for visual
Categories: Cytochrome P-450 CYP2C9 Inducers, Cytochrome P-450 Enzyme InducersSynonyms: 4-Amino-5-hexenoic acidAtaluren
go.drugbank.com/drugs/DB05016ApprovedWithdrawnAtaluren is a novel, orally administered drug that targets nonsense mutations. … More specifically, ataluren is used in the small group of patients whose disease is caused by a specific genetic defect (called a ‘nonsense mutation’) in the dystrophin gene.
Synonyms: 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acidCategories: Heterocyclic Compounds, 1-RingFerric pyrophosphate
go.drugbank.com/drugs/DB09147ApprovedInvestigationalFerric pyrophosphate is an iron replacement product. … The ferric ion is strongly complexed by pyrophosphate.[A31979] It presents an increasing interest as this insoluble form can be milder in the gastrointestinal tract and present higher bioavailability.
Mixtures: Tricare Prenatal 2-part Daily Prenatal Vitamin SystemCarfilzomib
go.drugbank.com/drugs/DB08889ApprovedInvestigationalCarfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsProducts: KYPROLIS®, KARFIB®N-alkyl ethylbenzyl dimethyl ammonium (C12-C14)
go.drugbank.com/drugs/DB11202ApprovedN-alkyl ethylbenzyl dimethyl ammonium (c12-c14) is a quaternary ammonium compound with surfactant properties. … and exposure, although the formal mechanism of action of quaternary ammonium compounds like n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride is difficult to elucidate.
Salts: N-alkyl ethylbenzyl dimethyl ammonium chloride (C12-C14)Mixtures: Prevent X Hand Sanitizer and Antiseptic Skin Protectant, Med-I-SanRelacorilant
go.drugbank.com/drugs/DB14976ApprovedInvestigationalRelacorilant is a first-in-class, selective glucocorticoid receptor antagonist. … Originally investigated to manage the metabolic and endocrinologic complications of hypercortisolism, such as Cushing’s syndrome, its clinical utility has pivoted toward oncology as a potent sensitizing
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP2C8 InducersLopinavir
go.drugbank.com/drugs/DB01601ApprovedInvestigational[saquinavir], [nelfinavir]), lopinavir is a peptidomimetic molecule - it contains a hydroxyethylene scaffold that mimics the peptide linkage typically targeted by the HIV-1 protease enzyme but which itself … Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection.
Mixtures: LOPIMUNE®, LOPIMUNE®Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsAcridine Carboxamide
go.drugbank.com/drugs/DB11880InvestigationalAcridine Carboxamide has been used in trials studying the treatment of Lung Cancer and Brain and Central Nervous System Tumors.
Synonyms: 4-ACRIDINECARBOXAMIDE, N-(2-(DIMETHYLAMINO)ETHYL)-, N-(2-(DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDECategories: Topoisomerase II Inhibitors, Heterocyclic Compounds, 3-Ring