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Tocofersolan
go.drugbank.com/drugs/DB11635ApprovedTocofersolan is an oral treatment of vitamin E deficiency due to digestive malabsorption in pediatric patients with congenital chronic cholestasis or hereditary chronic cholestasis. … D-Alpha-tocopheryl polyethylene glycol 1000 succinate (Tocofersolan, Vedrop), has been developed in Europe as an orally bioavailable source of vitamin E in children suffering from cholestasis [L2371].
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: D-.ALPHA.-TOCOPHEROL POLYETHYLENE GLYCOL 1000 SUCCINATEAlbiglutide
go.drugbank.com/drugs/DB09043ApprovedInvestigationalWithdrawnAlbiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant ...
Edrophonium
go.drugbank.com/drugs/DB01010ApprovedIt has also been used as an antidote to curare principles.
Dimethylthiambutene
go.drugbank.com/drugs/DB01444ExperimentalIllicitDimethylthiambutene (N,N-Dimethyl-1-methyl-3,3-di-2-thienylallylamine, Dimethibutin, Ohton) is an opioid analgesic drug. … It is now under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse potential, although little more information is available.
Synonyms: 3-dimethylamino-1,1-di-(2'-thienyl)-1-butene, N,N,1-trimethyl-3,3-di-2-thienylallylamineRoxadustat
go.drugbank.com/drugs/DB04847ApprovedInvestigationalRoxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. It works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transc...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesOportuzumab monatox
go.drugbank.com/drugs/DB05319InvestigationalVB4-845 is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells.
Carvedilol
go.drugbank.com/drugs/DB01136ApprovedInvestigationalCarvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: Nu-carvedilol, Ran-carvedilolMidodrine
go.drugbank.com/drugs/DB00211ApprovedInvestigationalAn ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesSynonyms: DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamidRibociclib
go.drugbank.com/drugs/DB11730ApprovedInvestigationalThese proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Ribociclib was approved by the FDA in March 2017 under the brand name Kisqali.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsResiquimod
go.drugbank.com/drugs/DB06530InvestigationalWhen put on the skin, resiquimod causes some immune cells to make certain chemicals that may help them kill tumor cells.