Dimethylthiambutene

DB01444ExperimentalIllicitSmall molecule

Dimethylthiambutene (N,N-Dimethyl-1-methyl-3,3-di-2-thienylallylamine, Dimethibutin, Ohton) is an opioid analgesic drug. It is now under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to...

Mechanism: Pharmacologically active on Mu-type opioid receptor
Curator reviewed
Primary indication: Dimethylthiambutene is an opioid analgesic previously used in moderate pain relief.Curator reviewed
Formula / weight: C₁₄H₁₇NS₂ · 263.421 g/mol (avg)
Also known as: Dimethibutin · Ohton

Resolves to

Compound

UNII915D88LM9OCAS524-84-5ChEMBLCHEMBL2106265ChEBI59781PubChem10668

Structure

InChIKeyCANBGVXYBPOLRR-UHFFFAOYSA-NSMILESCC(C=C(C1=CC=CS1)C1=CC=CS1)N(C)C

Targets

P35372OPRM1P41143OPRD1

What you can answer from here — as of September 20, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Dimethylthiambutene, and which of those have an active Phase 3 trial?

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