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Dasatinib
go.drugbank.com/drugs/DB01254ApprovedInvestigationalBCR-ABL is associated with the uncontrolled activity of the ABL tyrosine kinase and is involved in the pathogenesis of CML and 15-30% of ALL cases. … [A11377,A33432] Dasatinib also inhibits a spectrum of kinases involved in cancer, including several SRC-family kinases.
Synonyms: N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamideCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexTheophylline
go.drugbank.com/drugs/DB00277ApprovedInvestigationalMechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. … A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities.
Synonyms: 1,3-dimethyl-7H-purine-2,6-dioneInternational brands: Theodur G, Theo 24Cilazapril
go.drugbank.com/drugs/DB01340ApprovedInvestigationalIt is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries, among many other names. None of these varieties are available in the United States. … It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat.
Mixtures: INHIBACE PLUS 5 MG TABLET, 28 ADET, İNHİBACE PLUS 5 MG/12,5 MG FILM KAPLI TABLET, 28 ADETCategories: Agents Acting on the Renin-Angiotensin System, P-glycoprotein inhibitorsMorphine
go.drugbank.com/drugs/DB00295ApprovedInvestigationalMorphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805.[A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. … Morphine was granted FDA approval in 1941.[L12114]
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesSynonyms: (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol, (7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diolEtoposide
go.drugbank.com/drugs/DB00773ApprovedInvestigationalAccumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. … A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.
Synonyms: 9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one, 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)International brands: Vepesid KCoagulation Factor IX Human
go.drugbank.com/drugs/DB13152ApprovedInvestigationalDeficiency of this protein causes hemophilia B.
Synonyms: Antihemophilic factor BMixtures: COFACT 250 IU/10 ML IV ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 1 ADET, COFACT 500 IU/20 ML IV ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 1 ADETMeperidine
go.drugbank.com/drugs/DB00454ApprovedInvestigationalA narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: Demerol 75 mg/ml, ALDOLAN 100 MG/2 ML AMPUL, 25 ADETPiperazine
go.drugbank.com/drugs/DB00592ApprovedVet approvedWithdrawnFirst used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. … Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: MEI-MEI WORM SYRUP 750 mg/5 ml, OBAT CACING U3Famotidine
go.drugbank.com/drugs/DB00927ApprovedInvestigationalFamotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. … [L11166] Compared to other H<sub>2</sub> receptor antagonists, famotidine displays high selectivity towards this receptor; in a study consisting of healthy volunteers and patients with acid hypersecretory
Synonyms: 3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidine, N-Sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamideInternational brands: Sedanium-RTeriparatide
go.drugbank.com/drugs/DB06285ApprovedInvestigational[A251395] First approved in the United States in November 2002 and in Europe in April 2003,[A251400] teriparatide makes the first approved drug in a new category of osteoporosis therapy called anabolic … Teriparatide is a recombinant parathyroid hormone (PTH) analog and a potent osteoanabolic agent.[A251395] It is made up of the first amino(N)-terminal 34 amino acids of the human PTH.
Synonyms: PTH 1-34, PTH (1-34)Products: FORTEO 250 UG SOLUTION FOR INJECTION, FORTEO® 250MCG/ML