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Rizatriptan
go.drugbank.com/drugs/DB00953ApprovedInvestigational[L46018] Used in the treatment of migraines, rizatriptan was first approved in the US in 1998. … Rizatriptan is a second-generation triptan [A258918] and a selective 5-HT<sub>1B and 5-HT1D</sub> receptor agonist.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Serotonin Receptor AgonistsOlsalazine
go.drugbank.com/drugs/DB01250Approved[A257063] It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. … [A257063] Olsalazine is used in the treatment of ulcerative colitis.[L45023,L45151]
Omega-3-carboxylic acids
go.drugbank.com/drugs/DB09568ApprovedWithdrawnThe omega-3 carboxylic acid (OM3-CA) is a new formulation of omega-3 fatty acids that present an enhanced bioavailability in the treatment of dyslipidemia. … The increased bioavailability is explained because OM3-CA is found in a form of polyunsaturated free fatty acids as opposed to other products whose form is as ethyl esters.
Clorazepic acid
go.drugbank.com/drugs/DB00628ApprovedIllicitSimilar to other benzodiazepines, the active metabolite of clorazepate enhances the binding of gamma-aminobutyric acid (GABA) to the GABA type A (GABA-A) receptor, which promotes channel opening and neuronal … Also, the use of clorazepate exposes users to users to the risks of abuse, misuse, and addiction, and its continued use may lead to significant physical dependence.
Products: Tranxene T-Tab, Clorazepate Dipotassium T-TabQuinidine
go.drugbank.com/drugs/DB00908Approved[A38016] Due to its side effects and increased risk of mortality, the use of quinidine was reduced over the next few decades. … Quinidine is a D-isomer of [quinine] present in the bark of the Cinchona tree and similar plant species.
Categories: Adrenergic alpha-1 Receptor AntagonistsArbutamine
go.drugbank.com/drugs/DB01102ApprovedArbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in … diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately .
Categories: Adrenergic beta-1 Receptor Agonists, Adrenergic beta-2 Receptor AgonistsBarium sulfate
go.drugbank.com/drugs/DB11150ApprovedBarium sulfate is an inorganic compound with the chemical formula BaSO4 [L1957]. Barium sulfate occurs in nature as the mineral _barite_. … Barium sulfate is ingested by mouth or administered rectally and combined with granules of effervescent bicarbonate to enhance distension of the GI tract, allowing for enhanced gastrointestinal tract visualization
Mixtures: E-Z HD SULFATODE BARIO PARA SUSPENSION, E-Z HD SULFATODE BARIO PARA SUSPENSIONProducts: E-Z-HD, E-Z PAQUE SULFATO DE BARIO PARA SUSPENSIONCrisaborole
go.drugbank.com/drugs/DB05219ApprovedInvestigationalIt reduces the local inflammation in the skin and prevents further exacerbation of the disease with a good safety profile. … Its structure contains a boron atom, which facilitates skin penetration and binding to the bimetal center of the phosphodiesterase 4 enzyme.
Bezlotoxumab
go.drugbank.com/drugs/DB13140Approved[L46976] First approved by the FDA on October 21, 2016,[A260106] bezlotoxumab is used to reduce the recurrence of _C. difficile_ infection. … [A260106] The drug was granted full approval by the EMA on January 18, 2017.[L47191]
Calcium polycarbophil
go.drugbank.com/drugs/DB14684ApprovedPolycarbophil is used to treat constipation. This drug may also be used to help relieve the symptoms of irritable bowel syndrome or diarrhea. … The material possesses exceptionally high water-binding capacity. is not absorbed, does not interfere with the activity of digestive enzymes or intestinal absorption, possesses satisfactory stability,