Barium sulfate



Barium sulfate is a contrast agent used for CT scans of the gastrointestinal tract.

Brand Names
E-Z-HD, E-Z-Paque, Readi-cat 2
Generic Name
Barium sulfate
DrugBank Accession Number

Barium sulfate is an inorganic compound with the chemical formula BaSO4 3.

Barium sulfate occurs in nature as the mineral barite. It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield 3.

This drug is used as a contrast agent in diagnostic x-ray procedures. Therapeutic advantages of barium sulfate in diagnostic procedures include both its low water solubility and high level of clearance from the body Label.

Barium sulfate is ingested by mouth or administered rectally and combined with granules of effervescent bicarbonate to enhance distension of the GI tract, allowing for enhanced gastrointestinal tract visualization 3, 5.

Small Molecule
Average: 233.39
Monoisotopic: 233.856970451
Chemical Formula
  • Bario sulfato
  • Barium sulfate
External IDs
  • CI 77120



Barium sulfate is a radiographic contrast agent indicated for use in computed tomography (CT) of the abdomen to delineate the gastrointestinal (GI) tract in adult and pediatric patients Label.

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Diagnostic agentRadiologic examination of the gastrointestinal tract•••••••••••••••••• •••••••••••••••• ••••••• ••• ••••••••• ••••••• ••• ••••••••••• ••••••••••
Contraindications & Blackbox Warnings
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Barium sulfate increases the absorption of x-rays as they are passed throughout the body, delineating body structures, in which barium sulfate is localized. This allows for the clear visualization of normal organs/defect in normal anatomy 5.

Mechanism of action

Barium sulfate is a heavy metal with a high atomic number (Z=56) and a K shell binding energy (K-edge of 37.4 keV) very close to that of most diagnostic x-ray beams. Due to these characteristics, barium is an ideal medium for the absorption of x-rays Label.

Barium sulfate is essentially not absorbed from the GI tract nor metabolized in the body. Barium sulfate is used to fill the gastrointestinal tract lumen or to coat the mucosal surface and is administered orally, rectally, or instilled into an enterostomy tube or catheter Label, 5.

Barium sulfate enhances delineation of the GI tract. The barium suspension covers the mucosal surface of the GI tract, allowing its shape, distensibility, motion, integrity, continuity, location within the torso, relationship to other organs to be closely examined 5. Various abnormalities, such as benign or malignant tumors, ulcers, strictures, diverticula, inflammation or infection, altered motility, displacement and other pathology can thereby be identified Label, 5.

At lower concentrations (higher dilution), barium enhances the conspicuity of the GI tract to differentiate the GI tract from various abdominal organs in computed tomography examinations (CT scans) of the abdomen. Improved delineation of the gastrointestinal tract lumen and mucosa may be reached by contrast provided by gas (by the addition of bicarbonate or gas-filled balloons) in addition to the barium 5. This is known as a double-contrast procedure. Osmotically active agents (for example, sorbitol) are also used to induce fluid accumulation and distension of the GI system to enhance visualization 5.


Barium sulfate is not absorbed following oral or rectal administration with a normal gastrointestinal tract. In patients with a normal GI tract, barium sulfate is normally excreted within 24 hr after oral ingestion. Post rectal administration of barium sulfate suspensions, the drug is generally excreted when the enema is released. Some barium may remain in the colon for several weeks, however, and eventually clears, especially in patients with impaired intestinal peristalsis 3. It is difficult to quantify the uptake of ingested barium because of a number of factors affect its absorption. The presence of sulfate in food can cause the precipitation of barium sulfate 3.

The following is the approximate time to peak opacification of organs by barium sulfate in a healthy GI tract:

Esophagus, stomach, and duodenum uptake of barium sulfate occurs almost immediately after oral administration 4.

Small intestine uptake is dependent on gastric emptying rate and viscosity of the preparation; it may be delayed 15-90 minutes post ingestion 4.

Small intestine (enteroclysis studies) uptake is immediate, following direct instillation 4.

Colon and distal small intestine uptake are dependent on patient positioning. Hydrostatic pressure also determines the rate and degree of opacification 4.

Volume of distribution

Not Available

Protein binding

Not Available


Barium sulfate is poorly water soluble and shows negligible levels of absorption from the gastrointestinal tract following both oral or rectal administration. In healthy subjects, orally administered barium sulfate is generally excreted within 24 hours. Rectally administered barium sulfate is eliminated with clearance of the enema 5.

Route of elimination

Barium sulfate is excreted unchanged in the feces 3.


Not Available


The rate of excretion of barium sulfate is dependent on the route of administration and the status of peristaltic activity and motility of the gastrointestinal tract 5.

Adverse Effects
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Acute Exposure

Nausea, vomiting, diarrhea and abdominal cramping may occur Label. Acute exposure to barium sulfate may irritate the eyes and respiratory tract. Exposure to inhalation or other forms can affect the nervous system and lead to hypokalemia, which can contribute to cardiovascular rhythm abnormality 3. Hypersensitivity, gastrointestinal transit delay, obstruction, aspiration pneumonitis and systemic embolization of barium sulfate are more serious complications of administration Label. In addition, fatalities have occurred due to aspiration pneumonitis, barium sulfate impaction, intestinal perforation with subsequent peritonitis and granuloma formation, and vasovagal and syncopal episodes Label, 2.

*Chronic Exposure *

The lungs may be affected by repeated or prolonged exposure to dust particles, resulting in baritosis (a type of benign pneumoconiosis) 3. Inhalation of barium sulfate dust may lead to a benign pneumoconiosis ("baritosis") with conspicuous radiographic characteristics but no signs of impairment of pulmonary function 3.

Intra-abdominal leakage

Intra-abdominal leakage may occur during or after administration of barium sulfate Label,5. Caution is advised in patients with a history of food aspiration and in patients with diagnosed swallowing disorders Label.

** A note on GI perforation**

Perforation of the colon after rectal administration of barium sulfate suspension has been reported due to the increased hydrostatic pressure of the instilled suspension, trauma to the colon from an enema tip, or forceful or deep insertion of a non-flexible enema tip. Perforation of the bowel has been followed by peritonitis, adhesions, granulomas, and death 4. This is a rare occurrence. Injury to the rectal mucosa or anal canal due to the enema tip or retention balloon is likely the most common traumatic cause of perforation during treatment. Inflation of a balloon within a stricture, neoplasm, inflamed rectum, or stoma is hazardous, and caution should be exerted 1.

Carcinogenicity and mutagenicity

No animal studies have been performed to evaluate the carcinogenicity of barium sulfate or potential effects on reproduction Label. Elective contrast radiography of the abdomen is not routintely recommended during pregnancy because of the risks to the fetus from radiation exposure 4.

Not Available
Pharmacogenomic Effects/ADRs
Not Available


Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.


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Active Moieties
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
AnatrastPaste560 mg/1gRectalMallinckrodt2009-06-012011-10-31US flag
Anatrast Pst 55%Paste55 %RectalTyco Healthcare1988-12-312010-01-07Canada flag
BariconFor suspension.98 g/1gOralMallinckrodt2009-12-012011-04-30US flag
Baricon for SuspensionPowder, for suspension98 %OralTyco Healthcare1988-12-312010-01-07Canada flag
Baro Bag Enema 98%Enema98 %RectalTyco Healthcare1984-12-312010-01-07Canada flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
BARYTGEN DE LUXE POWDERPowder97.98 g/100gOralEISAI (SINGAPORE) PTE. LTD.1991-05-24Not applicableSingapore flag
Polibar Rapid 57% (p/p)Suspension57 %RectalTherapex Division De E Z Em Canada Inc1989-12-312009-08-04Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
E-Z HD SULFATODE BARIO PARA SUSPENSIONBarium sulfate (88.6272 g) + Barium sulfate (9.8258 g)Powder, for suspensionOralAJOVECO S.A.S.2007-06-07Not applicableColombia flag
E-Z HD SULFATODE BARIO PARA SUSPENSIONBarium sulfate (88.6272 g) + Barium sulfate (9.8258 g)Powder, for suspensionOralAJOVECO S.A.S.2007-06-07Not applicableColombia flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
AnatrastBarium sulfate (560 mg/1g)PasteRectalMallinckrodt2009-06-012011-10-31US flag
BariconBarium sulfate (.98 g/1g)For suspensionOralMallinckrodt2009-12-012011-04-30US flag
Baro-catBarium sulfate (15 mg/1mL)SuspensionOral; RectalMallinckrodt2009-06-012011-03-31US flag
Barobag Enema KitBarium sulfate (.97 g/1g)Powder, for suspensionRectalMallinckrodt2009-06-012011-10-31US flag
Barobag Enema KitBarium sulfate (.97 g/1g)Powder, for suspensionRectalMallinckrodt2009-06-012011-10-31US flag


ATC Codes
V08BA01 — Barium sulfate with suspending agentsV08BA02 — Barium sulfate without suspending agents
Drug Categories
Chemical TaxonomyProvided by Classyfire
This compound belongs to the class of inorganic compounds known as alkaline earth metal sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is an alkaline earth metal.
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Alkaline earth metal oxoanionic compounds
Sub Class
Alkaline earth metal sulfates
Direct Parent
Alkaline earth metal sulfates
Alternative Parents
Inorganic salts / Inorganic oxides
Alkaline earth metal sulfate / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
  • Humans

Chemical Identifiers

CAS number
InChI Key
barium(2+) sulfate


General References
  1. Williams SM, Harned RK: Recognition and prevention of barium enema complications. Curr Probl Diagn Radiol. 1991 Jul-Aug;20(4):123-51. [Article]
  2. Hoevels J, Thermann M: [Barium sulfate and water-soluble contrast medium--a suitable mixture for contrast radiography in acute small bowel obstruction]. Zentralbl Chir. 2003 Jun;128(6):500-5. doi: 10.1055/s-2003-40624. [Article]
  3. Barium Sulfate PubChem [Link]
  4. Barium Sulfate, [Link]
  5. NDA, Barium Sulfate [Link]
  6. FDA Approved Drug Products: E-Z-CAT DRY (barium sulfate) for oral suspension [Link]
PubChem Compound
PubChem Substance
FDA label
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Clinical Trials

Clinical Trials
4CompletedDiagnosticPatients With Potential Colorectal Neoplasia1
Not AvailableCompletedNot AvailableAging / Deglutition / Healthy Swallowing1
Not AvailableCompletedNot AvailableKnown or Suspected Abdominal Disease1


Not Available
Not Available
Dosage Forms
Powder, for suspensionRectal96.4788 g
PasteRectal560 mg/1g
PasteRectal55 %
Powder, for suspensionOral98 %
Powder, for solutionOral10 g
SuspensionOral2 g
Powder, for suspensionRectal97.4 g
Powder, for suspensionOral98 g
PowderRectal97.4 g
EnemaRectal98 %
SuspensionOral; Rectal15 mg/1mL
Powder, for suspensionRectal.97 g/1g
SuspensionOral; Rectal1.5 %
Powder, for suspensionOral; Rectal.95 g/1g
Injection, powder, for solutionParenteral97 g
EnemaRectal95 %
Powder, for suspensionOral; Rectal95 %
Suspension150 g/240ml
PowderOral97.98 g/100g
SuspensionOral; Rectal2.2 %
SuspensionOral; Rectal22 mg/1mL
SuspensionOral4.9224 g
Powder, for suspensionOral
Powder, for suspensionOral; Rectal96.3096 g
Powder, for suspensionOral400 mg/1g
Powder, for suspensionOral9.5 g/23g
TabletOral700 mg/1
SuspensionRectal1.05 g/1mL
Powder, for suspensionOral980 mg/1g
Powder, for suspensionOral960 mg/1g
SuspensionOral0.6 g/1mL
Powder, for solutionRectal95 %
Powder, for solutionOral; Rectal95 %
CreamOral.6 g/1g
Suspension11.025 g
Powder340 g
Powder, for solutionOral82 %
SuspensionOral240 mg/1mL
Powder, for suspensionOral81 g
PowderOral81 %
SuspensionOral500 mg/1mL
SuspensionOral50 %
SuspensionOral13 %
SuspensionOral130 mg/1mL
CreamOral60 g / 100 g
PasteRectal45 %
SuspensionRectal1000 mg/1mL
SuspensionRectal100 %
For suspensionOral.98 g/1g
For suspensionOral; Rectal.85 g/1mL
SuspensionOral; Rectal51 %
SuspensionOral98 %
PasteOral440 mg/1g
PasteOral44 %
Suspension400 g
Suspension5000 g
SuspensionOral2100 mg/1mL
SuspensionOral210 %
SuspensionOral; Rectal600 mg/1mL
SuspensionOral; Rectal60 %
SuspensionOral; Rectal1.05 g/1mL
LiquidOral210 g / 100 mL
SuspensionOral; Rectal1000 mg/1mL
SuspensionOral; Rectal56 %
SuspensionOral; Rectal1 g/ml
SuspensionOral50 mg/ml
Powder, for suspensionRectal965 mg/1g
SuspensionRectal57 %
Powder397 gr
SuspensionOral; Rectal150 mg/1mL
LiquidOral; Rectal1.5 %
Powder, for suspensionRectal96.48 g
Powder, for suspensionRectal383.02 g
Powder, for suspensionOral98.45 G
Powder, for suspensionOral334.74 g
Suspension1 g/ml
Suspension960 ml
Suspension240 ml
Suspension240 g/240ml
Suspension150 ml
SuspensionOral13 mg/1mL
SuspensionOral20 mg/1mL
SuspensionOral21 mg/1mL
SuspensionOral; Rectal21 mg/1mL
SuspensionOral; Rectal11.07 g/225ml
SuspensionOral400 mg/1mL
SuspensionOral; Rectal5 %
SuspensionOral; Rectal50 mg/1mL
For suspensionOral; Rectal.95 g/1g
PowderOral; Rectal95 %
Powder, for suspensionOral; Rectal98 g/100g
Powder, for suspensionOral; Rectal96 g/100g
PasteOral400 mg/1mL
Powder, for suspensionOral.81 g/1g
Powder, for suspensionRectal960 mg/1g
Powder, for suspensionOral; Rectal980 mg/1g
SuspensionOral1 mg/1mL
Powder, for suspensionOral6 g/20ml
Not Available
Not Available


Experimental Properties
melting point (°C)1580MSDS
boiling point (°C)decomposesMSDS
water solubilityVery slightly soluble in cold waterMSDS
Predicted Properties
pKa (Strongest Acidic)-3Chemaxon
Physiological Charge-2Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area80.26 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity11.53 m3·mol-1Chemaxon
Polarizability5.81 Å3Chemaxon
Number of Rings0Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available


Mass Spec (NIST)
Not Available
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-001i-0090000000-c1ab5d057cf9c5696620
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at December 03, 2015 16:51 / Updated at February 21, 2021 18:52