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Lacosamide
go.drugbank.com/drugs/DB06218ApprovedInvestigationalLacosamide is an antiepileptic drug used to treat seizures. As a chiral functionalized amino acid, it works by blocking slowly inactivating components of voltage-gated sodium currents. … Lacosamide exhibits a stereoselective mode of interaction with sodium channels.
Synonyms: (R)-LACOSAMIDE 1, (R)-2-acetamido-N-benzyl-3- methoxypropionamideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesLonafarnib
go.drugbank.com/drugs/DB06448ApprovedInvestigational[A224379, A224384, A224389, A224394, A224399] Mechanistically, HGPS is underpinned by a single heterozygous C-to-T mutation at position 1824 of the _LMNA_ gene, which results in the accumulation of an … [A224379, A224394] Lonafarnib is a farnesyl transferase (FTase) inhibitor (FTI), which reduces the farnesylation of numerous cellular proteins, including progerin; as progerin farnesylation is important
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesL-tartaric acid
go.drugbank.com/drugs/DB09459Approved, and is a dihydroxyl derivative of succinic acid. … Tartaric acid is a white crystalline organic acid that occurs naturally in many plants, most notably in grapes.Tartaric is an alpha-hydroxy-carboxylic acid, is diprotic and aldaric in acid characteristics
Mixtures: E-Z-gas 2 Granules, SAL G.Synonyms: (+)-(R,R)-tartaric acid, (R,R)-Tartaric acidFingolimod
go.drugbank.com/drugs/DB08868ApprovedInvestigational[A176474] Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. … Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects.
Categories: P-glycoprotein inducers, Cytochrome P-450 SubstratesProducts: DROPTON®, GENBIEMOD®Medrogestone
go.drugbank.com/drugs/DB09124ApprovedWithdrawnMedrogestone (INN), also known as 6,17α-dimethyl-6-dehydroprogesterone, is a progestational agent derived from 17-methylprogesterone. … [A31526] It was developed by Ayerst, approved in Canada in 1969 and its current status is cancelled post-marketing.[L1118] It was never approved by the FDA.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesPemetrexed
go.drugbank.com/drugs/DB00642ApprovedInvestigationalPemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta. … Pemetrexed was first approved by the FDA in February 4, 2004.[A253907]
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: Pemetrexed Krka Page 1/1, SUMITREXED®Coumermycin A1
go.drugbank.com/drugs/DB13912ExperimentalCategories: Topoisomerase II Inhibitors, Heterocyclic Compounds, 1-RingGrazoprevir
go.drugbank.com/drugs/DB11575ApprovedGrazoprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotypes 1 and 4 [synthesis]. … HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients [L852].
Mixtures: ZEPATIER® TABLETAS RECUBIERTASCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesBaxdrostat
go.drugbank.com/drugs/DB19090ApprovedInvestigationalBaxdrostat is an orally bioavailable, highly selective, first-in-class small-molecule aldosterone synthase inhibitor (ASI) designed to block the production of aldosterone [A275512]. … It targets aldosterone excess, a primary underlying driver of treatment resistance and organ damage in cardiovascular diseases [A275512, A275515].
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: (+)-(r)-n-(4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide, N-((8r)-5,6,7,8-tetrahydro-4-(1,2,3,4-tetrahydro-1-methyl-2-oxo-6-quinolinyl)-8-isoquinolinyl)propanamideCalcium carbimide
go.drugbank.com/drugs/DB09116ApprovedWithdrawnCalcium carbimide was conceived as an alternative for the treatment of alcoholism with a reduced side effect profile either when it is consumed accompanied by alcohol or without it. … Calcium carbimide, sold as the citrate salt, is an alcohol-sensitizing agent.
Synonyms: Cyanamide, calcium salt (1:1), methanediimine, calcium salt (1:1)