Search

Displaying results 2241 - 2250 of 3889 in total
  1. Drug

    Lutetium Lu 177 dotatate

    go.drugbank.com/drugs/DB13985
    ApprovedInvestigational

    uptakes or deciding the dose for subsequent administrations [A31702]. … The presence of a radioligand allows monitoring of treatment response post therapy and prior to next fraction of the dose delivery which may be clinically beneficial in estimating the intensity of lesion

  2. Drug

    Macimorelin

    go.drugbank.com/drugs/DB13074
    Approved

    In clinical studies involving healthy subjects, macimorelin stimulated GH release in a dose-dependent manner with good tolerability [A31481]. … More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dependently increase GH levels

  3. Drug

    Iohexol

    go.drugbank.com/drugs/DB01362
    ApprovedInvestigational

    Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chem...

  4. Drug

    PF-04995274

    go.drugbank.com/drugs/DB12675
    Investigational

    Pf 04995274 is under investigation in clinical trial NCT01193062 (Study In Healthy Subjects To Evaluate The Changes In The Protein sAPP-Alpha In Cerebrospinal Fluid Following A Single Oral Dose Of PF-04995274

  5. Target

    N-lysine methyltransferase KMT5A

    go.drugbank.com/bio_entities/BE0019990
    TargetHumans

    Nucleosomes are preferred as substrate compared to free histones (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599).

    Synonyms: SET domain-containing protein 8, PR/SET domain-containing protein 07
  6. Drug

    Tasonermin

    go.drugbank.com/drugs/DB11626
    Approved

    Tasonermin is recombinant soluble form tumor necrosis factor α produced via Escherichia coli cell culture. It was approved for use by the European Medicines Agency in April of 1999 for use as an adjunt to surgery for the subsequent remov...

  7. Drug

    AV-412

    go.drugbank.com/drugs/DB06021
    Investigational

  8. Drug

    Tegaserod

    go.drugbank.com/drugs/DB01079
    ApprovedWithdrawn

    Novartis' brand name Zelnorm (tegaserod) had originally received approval from the US FDA in 2002 for the treatment of irritable bowel syndrome with constipation (IBS-C). It was, however, voluntarily withdrawn from widespread use in the ...

  9. Indication

    Lung Cancer

    go.drugbank.com/conditions/DBCOND0028388
    Drugs: Cyclophosphamide · Uracil
    Synonyms: Malignant neoplasm of unspecified part of unspecified bronchus or lung
  10. Drug

    Oliceridine

    go.drugbank.com/drugs/DB14881
    ApprovedInvestigational

    Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors. … [A218026, A218031] By acting as a biased agonist, oliceridine provides comparable analgesia compared with traditional opioids such as [morphine] at a comparable or decreased risk of opioid-related adverse