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Displaying results 2251 - 2260 of 8196 in total
  1. Drug

    Vonoprazan

    go.drugbank.com/drugs/DB11739
    ApprovedInvestigational

    Unlike proton-pump inhibitors, PCABs are not affected by CYP2C19 genetic polymorphisms and do not require acid-resistant formulations. … PCABs represent an alternative to proton-pump inhibitors for the treatment of acid-related disorders.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  2. Drug

    Histrelin

    go.drugbank.com/drugs/DB06788
    ApprovedInvestigationalWithdrawn

    [L41710] GnRH agonists are the first line of treatment for children with central precocious puberty (CPP) due to their capacity to reduce LH levels and the concentration of sex steroids. … Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses.

    Synonyms: [(im-Bzl)-D-His6,Pro9-NEt]-gonadotropin releasing hormone, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
  3. Drug

    Telotristat ethyl

    go.drugbank.com/drugs/DB12095
    Approved

    [L43367] Overexposure to serotonin can cause severe diarrhea, one of the main clinical symptoms of carcinoid syndrome. … [A252947] Neuroendocrine tumors (NET) arising from these cells can therefore secrete chemical mediators into the bloodstream to cause side effects in distant sites, a phenomenon called carcinoid syndrome

    Categories: Cytochrome P-450 CYP2B6 Inducers, P-glycoprotein inhibitors
  4. Drug

    Iophendylate

    go.drugbank.com/drugs/DB01187
    Approved

    In 1942 Van Wagenen (a neurosurgical colleague of Warrens, at the University of Rochester) identified Iophendylate as causing chemical meningitis in 30 patients where "space-displacing masses within the

    Synonyms: Ethyl 10-(p-iodophenyl)-undecanoate, Ethyl 10-(p-iodophenyl)undecylate
  5. Drug

    Isavuconazonium

    go.drugbank.com/drugs/DB06636
    ApprovedInvestigational

    Due to low solubility in water of isavuconazole on its own, the isovuconazonium formulation is favorable as it has high solubility in water and allows for intravenous administration.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP2B6 Inducers
  6. Drug

    Doxacurium

    go.drugbank.com/drugs/DB01135
    ApprovedWithdrawn

    Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration.

  7. Drug

    Botrytis cinerea

    go.drugbank.com/drugs/DB10428
    Approved

    Botrytis cinerea is a fungus which can provoke allergic reactions. Botrytis cinerea extract is used in allergenic testing.

  8. Drug

    Neurospora intermedia

    go.drugbank.com/drugs/DB10438
    Approved

    Neurospora intermedia is a fungus which can provoke allergic reactions. Neurospora intermedia extract is used in allergenic testing.

  9. Drug

    Stemphylium solani

    go.drugbank.com/drugs/DB10445
    Approved

    Stemphylium solani is a fungus which can provoke allergic reactions. Stemphylium solani extract is used in allergenic testing.

  10. Drug

    Aspergillus terreus

    go.drugbank.com/drugs/DB10450
    Approved

    Aspergillus terreus is a fungus which can provoke allergic reactions. Aspergillus terreus extract is used in allergenic testing.