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Ceftobiprole
go.drugbank.com/drugs/DB04918ApprovedWithdrawnCeftobiprole is a fifth-generation semisynthetic cephalosporin antibacterial which is available commercially as the prodrug [ceftobiprole medocaril]. … The EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a negative opinion of ceftobiprole medocaril in February 2010, recommending the refusal of its marketing authorization in the European
Categories: Heterocyclic Compounds, 2-RingrhThrombin
go.drugbank.com/drugs/DB04923ApprovedWithdrawnThrombin is used in more than 1 million surgeries each year in the United States. Currently, only thrombin derived from bovine blood is available in the U.S. as a stand-alone thrombin product. … ZymoGenetics is developing rhThrombin, a recombinant form of human thrombin that is not derived from animal or human blood, as an aid to controlling bleeding during surgery.
Itopride
go.drugbank.com/drugs/DB04924InvestigationalItopride is a dopamine D2 antagonist with acetylcholinesterase inhibitory actions.
Synonyms: N-(p-(2-(Dimethylamino)ethoxy)benzyl)veratramideXP12B
go.drugbank.com/drugs/DB04928InvestigationalXP12B is being developed by Xanodyne Pharmaceuticals for the treatment of menorrhagia (heavy menstrual bleeding). It was granted Fast Track status for this indication by the FDA in November 2004.
Afamelanotide
go.drugbank.com/drugs/DB04931ApprovedAfamelanotide is a first-in-class, synthetic, 13-amino acid peptide analogue of the endogenous alpha melanocyte-stimulating hormone (α-MSH). … [L9092] Despite its relatively recent approval, afamelanotide has been available for use as an orphan drug in both the US and EU since 2008.[L9122,L9125]
Categories: Melanocortin 1 Receptor (MC1-R) Agonists, Compounds used in a research, industrial, or household settingSynonyms: MT-I, Melanotan 1Eritoran
go.drugbank.com/drugs/DB04933InvestigationalEritoran is a structural analogue of the lipid A portion of lipopolysaccharide (LPS). It is being developed by Eisai Research Institute of Boston for the treatment of severe sepsis.
Categories: Toll-Like Receptor 4, antagonists & inhibitorsTagatose
go.drugbank.com/drugs/DB04936InvestigationalTagatose is a functional sweetener. It is a naturally occurring monosaccharide, specifically a hexose. … It is commonly found in dairy with a similar texture and sweetened capacity to sucrose but with only a third of the calories. It is approved as a food additive as a low calorie sweetener.
Categories: Compounds used in a research, industrial, or household settingSynonyms: (3S,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-one, D-lyxo-hex-2-uloseOspemifene
go.drugbank.com/drugs/DB04938ApprovedOspemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesSynonyms: 2-(p-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanol, 2-(4-(4-Chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanolIloperidone
go.drugbank.com/drugs/DB04946ApprovedInvestigationalIloperidone is a benzisoxazole [A263557] and an atypical antipsychotic agent that was first approved by the FDA on May 6, 2009. … [A3024] It is considered to be a second-generation antipsychotic drug [A263552] with multiple receptor binding profile, although it shows high affinity towards 5-HT<sub>2A</sub> and dopamine D2 receptors
Categories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor AntagonistsSynonyms: 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone, 4'-(3-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3'-methoxyacetophenoneRanpirnase
go.drugbank.com/drugs/DB04950InvestigationalRanpirnase is a ribonuclease enzyme found in <i>Rana pipiens</i> oocytes. It is being studied in the treatment of cancer. It is manufactured by Alfacell Corporation. … It is the first ribonuclease to enter cancer clinical trials.