Iloperidone

DB04946ApprovedInvestigationalSmall moleculeAntipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical])

Iloperidone is an atypical antipsychotic agent used to treat schizophrenia and manic or mixed episodes associated with bipolar I disorder in adults. Iloperidone is a benzisoxazole and an atypical antipsychotic agent that was first approved by the FDA on May 6, 2009.

Chemical structure of Iloperidone
Mechanism
Curator reviewed · 1 reference
Primary indication
Iloperidone is indicated for the treatment of schizophrenia in adults.Curator reviewed · 2 structured indications
Formula / weight
C24H27FN2O4 · 426.4806 g/mol (avg)
First approval
United States, 2009
Code names
HP-873 · ILO-522
Brand names
  • Fanapt

Resolves to

Compound
UNIIVPO7KJ050NCAS133454-47-4ChEMBLCHEMBL14376ChEBI65173PubChem71360KEGGD02666
Clinical / RWD
RxNorm73178ATCN05AX14PharmGKBPA161199368
Structure
InChIKeyXMXHEBAFVSFQEX-UHFFFAOYSA-NSMILESCOC1=C(OCCCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C=CC(=C1)C(C)=O
Targets
P28223HTR2AP14416DRD2P08908HTR1AP28335HTR2CP50406HTR6P34969HTR7P35348ADRA1AP08913ADRA2A+9 more

What you can answer from here — as of June 15, 2026

17Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
1,749Drug interactionsStructured to mechanism, not free text
Sign in
24Clinical trialsPhase, status and sponsor resolved per trial
Sign in
2Structured indicationsCondition, population, route and combination as fields, not prose
Sign in
1ContraindicationEach with its own population and attribute set
Sign in
65Marketed productsAcross 1 country and 6 labellers
Sign in
1ATC codeIncluding every combination product, plus 35 drug categories
Sign in
82+ReferencesStructured and connected to the statements they support
Sign in

Which drugs share a target with Iloperidone, and which of those have an active Phase 3 trial?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In