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Podophyllin
go.drugbank.com/drugs/DB09094ApprovedPodophyllin arrests mitosis in metaphase.
Categories: Compounds used in a research, industrial, or household settingLinezolid
go.drugbank.com/drugs/DB00601ApprovedInvestigational[L32965] Linezolid exerts its antibacterial activity by inhibiting the initiation of bacterial protein synthesis - more specifically, it binds to the 23S ribosomal RNA of the 50S subunit[A11227,A199050 … Linezolid was initially approved in 2000 and was the first member of the oxazolidinone antibiotic class.
Synonyms: N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamideProducts: LINEZOLID 600MG ZENTIVA FT, LINEZOLID 2MG/MLOlezarsen
go.drugbank.com/drugs/DB18728ApprovedInvestigational[L52033] On December 19, 2024, olezarsen was approved by the FDA for the treatment of familial chylomicronemia syndrome.[L52028] It is also being investigated for the treatment of hyperlipidemia. … Olezarsen is an antisense oligonucleotide that targets the messenger RNA (mRNA) for apolipoprotein C-III (APOC3, apoC-III),[L52033] which is a key regulator of triglyceride levels in plasma, in the liver
Synonyms: DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RU-M5C-T-T-G-T-M5C-M5C-A-G-M5C-(2'-O-(2-METHOXYETHYL)Bexagliflozin
go.drugbank.com/drugs/DB12236ApprovedInvestigationalIts use is not recommended in patients with type 1 diabetes since it may increase their risk of diabetic ketoacidosis.[L44758] … [A256423,L44758] In January 2023, bexagliflozin was approved by the FDA for the treatment of adults with type 2 diabetes.
Categories: Drugs Used in DiabetesLevocabastine
go.drugbank.com/drugs/DB01106ApprovedLevocabastine was discovered at Janssen Pharmaceutica in 1979.
Products: Levocamed 0,5 mg/ml Augentropfensuspension, Levocamed 0,5 mg/ml Nasenspray, SuspensionAnsuvimab
go.drugbank.com/drugs/DB16385ApprovedInfection with pathogenic filoviruses, such as _Zaire ebolavirus_ (Ebola virus, EBOV), can cause severe hemorrhagic fever in humans, resulting in frequent outbreaks with case fatality rates as high as … [A225943, A225948, A226035] A randomized, controlled trial of four investigational therapies for Ebola virus disease (EVD) in the Democratic Republic of Congo during a previous outbreak that began in 2018
Bepridil
go.drugbank.com/drugs/DB01244ApprovedWithdrawnIt is no longer marketed in the United States, as it has been implicated in causing ventricular arrhythmias (ie. Torsade de pointes). … It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
Synonyms: .-((2-METHYLPROPOXY)METHYL)-N-PHENYL-N-(PHENYLMETHYL)-, 1-(2-(N-BENZYLANILINO)-1-(ISOBUTOXYMETHYL)ETHYL)-PYRROLIDINEEtranacogene dezaparvovec
go.drugbank.com/drugs/DB16791ApprovedInvestigational[L44161] It is additionally notable for its cost per treatment - approximately 3.5 million USD - earning it the title of most expensive drug in the world. … [L44156] It delivers a copy of the deficient gene that results in cell transduction and an eventual increase in circulating factor IX activity.
Tasonermin
go.drugbank.com/drugs/DB11626ApprovedIt was approved for use by the European Medicines Agency in April of 1999 for use as an adjunt to surgery for the subsequent removal of the tumor and in palliative care for irresectable soft tissue sarcoma … It is administered with [DB01042] via mild hyperthermic isolated limb perfusion.
Amrinone
go.drugbank.com/drugs/DB01427ApprovedWithdrawnIt is used in the treatment of congestive heart failure.
Categories: Compounds used in a research, industrial, or household settingProducts: Inocor Liq 5mg/ml