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Displaying results 2321 - 2330 of 10000 in total
  1. Drug

    Posaconazole

    go.drugbank.com/drugs/DB01263
    ApprovedInvestigationalVet approved

    Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: POSIOLE® IV SOLUCIÓN PARA INFUSIÓN 300 MG/16.7 ML, NOXAFIL 300 MG INFÜZYON IÇIN KONSANTRE ÇÖZELTI ,1 ADET
  2. Drug

    Esmolol

    go.drugbank.com/drugs/DB00187
    ApprovedInvestigationalWithdrawn

    The FDA withdrew its approval for the use of all parenteral dosage form drug products containing esmolol hydrochloride that supply 250 milligrams/milliliter of concentrated esmolol per 10-milliliter ampule … Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesSynonyms: 3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester, (±)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate
  3. Drug

    Cannabidivarin

    go.drugbank.com/drugs/DB14050
    Investigational

    CBDV has also been shown to inhibit the activity of diacylglycerol (DAG) lipase-α, the primary enzyme responsible for the synthesis of the endocannabinoid, 2-arachidonoylglycerol (2-AG) [A33296, A33347 … It is one of over 100 cannabinoids identified from the Cannabis plant that can modulate the physiological activity of cannabis, or marijuana [A32584].

    Synonyms: 2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-propylbenzene-1,3-diol, CBD-V
  4. Drug

    Esketamine

    go.drugbank.com/drugs/DB11823
    ApprovedInvestigational

    [L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. … Esketamine is the s-enantiomer of [Ketamine]. Ketamine is a mixture of two enantiomers (mirror image molecules). This is the first time that the FDA has approved esketamine for any use.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersSynonyms: (S)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone, L-ketamine
  5. Drug

    Vinblastine

    go.drugbank.com/drugs/DB00570
    ApprovedInvestigational

    Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProducts: VINBLASTINE RICHTER 5 MG FLAKON, VINCABLAS® 10 MG/VIAL
  6. Drug

    Bisacodyl

    go.drugbank.com/drugs/DB09020
    ApprovedInvestigational

    [A233290,A233300,A207700] Bisacodyl was patented on 25 September 1956[L33045] but has been used as a laxative since 1952.[A233300] … Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.

    Synonyms: Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester)Mixtures: BEKUNIS 3 MG/5 MG KAPLI TABLET, 30 ADET, PCP 100 Kit
  7. Drug

    Emavusertib

    go.drugbank.com/drugs/DB18060
    Investigational

    Synonyms: 4-oxazolecarboxamide, n-(5-((3r)-3-hydroxy-1-pyrrolidinyl)-2-(4-morpholinyl)oxazolo(4,5-b)pyridin-6-yl)-2-(2-methyl-4-pyridinyl)-Categories: Heterocyclic Compounds, 1-Ring
  8. Drug

    S-55746

    go.drugbank.com/drugs/DB18365
    Investigational

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: (S)-N-(4-hydroxyphenyl)-3-(6-(3-(morpholinomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzo(d)(1,3)dioxol-5-yl)-n-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide
  9. Drug

    Gusacitinib

    go.drugbank.com/drugs/DB15670
    Investigational

    Gusacitinib is under investigation in clinical trial NCT02550678 (A Study of the Efficacy and Safety of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma).

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-(4-(4-(4-HYDROXY-PIPERIDIN-1-YL)-PHENYLAMINO)-5-OXO-5,6-DIHYDRO-PYRIMIDO(4,5-D)PYRIDAZIN-2-YL)-PIPERIDIN-4-YL-ACETONITRILE
  10. Drug

    5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide

    go.drugbank.com/drugs/DB07872
    Experimental

    Synonyms: 5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide