Cannabidivarin, also known as cannabidivarol or CBDV, is a non-psychoactive cannabinoid found within DB14009. It is one of over 100 cannabinoids identified from the Cannabis plant that can modulate the... Compared to its homolog, DB09061, CBDV is shortened by two methyl (CH2) groups on its side chain.
- Mechanism
- Curator reviewed · 5 references
The anti-epileptic activity of CBD and CBDV is thought to be modulated by their effects on transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor, which is part of a large family of ion channels that are involved in the onset and progression of several types of epilepsy. CBD and CBDV have been shown to dose-dependently activate and then desensitize TRPV1 as well as TRPV2 and TRPA1 channels. Desensitization of these ion channels is a potential mechanism by which these molecules cause a reduction of neuronal hyperexcitability that contributes to epileptic activity and seizures.
CBDV has also been shown to inhibit the activity of diacylglycerol (DAG) lipase-α, the primary synthetic enzyme of the endocannabinoid, 2-arachidonoylglycerol (2-AG). The clinical implications of this are unclear however, as this interaction has not been shown to affect CBDV's anticonvulsant activity.
- Primary indication
- Cannabidivarin does not currently have any FDA or Health Canada approved indications, however in October 2017 CBDV was given orphan designation by the European Medicines Agency for use in Rett Syndrome and again in February...Curator reviewed
- Formula / weight
- C19H26O2 · 286.415 g/mol (avg)
- Also known as
- cannabidivarine · Cannabidivarol · CBD-V · CBDV
- Code names
- GWP-42006
Resolves to
REOZWEGFPHTFEI-JKSUJKDBSA-NSMILES[H][C@]1(CCC(C)=C[C@H]1C1=C(O)C=C(CCC)C=C1O)C(C)=CWhat you can answer from here — as of April 23, 2025
Which drugs share a target with Cannabidivarin, and which of those have an active Phase 3 trial?
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