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Atazanavir
go.drugbank.com/drugs/DB01072ApprovedInvestigationalAtazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses per day) and has lesser effects on the patient's lipid profile (the amounts of cholesterol … and other fatty substances in the blood).
Mixtures: ANCEF ® R, ANCEF ® RCategories: Antivirals used in combination for the treatment of HIV infections, P-glycoprotein inducersTriclocarban
go.drugbank.com/drugs/DB11155ApprovedIt is a bacteriostatic compound that has been found in antibacterial soaps and other personal care products. … In 2017, the US FDA prohibited the marketing of over-the-counter (OTC) consumer antiseptic wash products containing triclocarban due to negative health effects such as bacterial resistance or hormonal
Synonyms: N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea, 1-(3',4'-dichlorophenyl)-3-(4'-chlorophenyl)ureaProducts: NEXT 1 Anti-bacterial, Next 1 Anti-Bacterial SportPhenylbutyric acid
go.drugbank.com/drugs/DB06819ApprovedInvestigationalPhenylbutyric acid is a fatty acid and a derivative of [butyric acid] naturally produced by colonic bacteria fermentation. … It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting as a chemical chaperone.
Synonyms: 4-Phenyl-n-butyric acid, γ-Phenyl-n-butyric acidCategories: Ammonium Ion Binding Activity, Cytochrome P-450 CYP2D6 InhibitorsCalcium lactate
go.drugbank.com/drugs/DB13231ApprovedVet approvedCalcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common. … Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+).
Synonyms: Calcium 2-hydroxypropanoate (1:2), Hemicalcium L-lactateMixtures: Min-tran Tab, Calcium Lactate Et Magnesium SulfateDeferasirox
go.drugbank.com/drugs/DB01609ApprovedInvestigationalDeferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 CYP3A InducersProducts: DEFERASIROX EG, RASIROX® 250MGATG-Fresenius S
go.drugbank.com/drugs/DB05320InvestigationalATG-Fresenius S is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits after immunization with a T-lympoblast cell line. … ATG-Fresenius S is an immunosuppressive product for the prevention and treatment of acute rejection following organ transplantation.
Synonyms: ATG-Fresenius SAT2220
go.drugbank.com/drugs/DB05200InvestigationalAT2220 has been shown to increase GAA activity in cell lines derived from Pompe patients and in transfected cells expressing misfolded forms of GAA. … It is a small molecule designed to act as a pharmacological chaperone that specifically binds, stabilizes, and facilitates the proper folding and trafficking of α-glucosidase (GAA).
Hexaminolevulinate
go.drugbank.com/drugs/DB06261ApprovedInvestigationalHexaminolevulinate is manufactured under the brand Cysview® by Photocure ASA. In Europe, Hexaminolevulinate is marketed under the brand Hexvix®. … Hexaminolevulinate is an optical imaging drug. In solution form it is instilled intravesically for use with photodynamic blue light cystoscopy as an adjunct to white light cystoscopy.
Synonyms: 4-Hexyloxycarbonyl-2-oxobutylammoniumchloride, Hexyl 5-amino-4-oxopentanoate hydrochlorideDostarlimab
go.drugbank.com/drugs/DB15627ApprovedInvestigationalA prospective phase II study in patients with mismatch repair-deficient locally advanced rectal cancer resulted in all twelve patients exhibiting a complete clinical response.[A248905] … Dostarlimab is an IgG<sub>4</sub> humanized monoclonal antibody targeted against the human programmed death receptor-1 (PD-1).
Synonyms: Immunoglobulin G4, anti-programmed cell death protein 1 (PDCD1) (humanized clone ABT1 gamma4-chain), disulfide with humanized clone ABT1 kappa-chain, dimerCategories: PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsMaralixibat
go.drugbank.com/drugs/DB16226ApprovedInvestigational[L38834] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended maralixibat be granted marketing authorization for the treatment of cholestatic pruritus in patients … with Alagille syndrome:[L43547] it was granted marketing authorization in Europe on 13 December 2022.
Categories: Cytochrome P-450 CYP3A Inhibitors, Heterocyclic Compounds, 2-Ring