Identification
- Summary
Calcium lactate is an ingredient found in a variety of nutritional products.
- Generic Name
- Calcium lactate
- DrugBank Accession Number
- DB13231
- Background
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener 1. Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
- Type
- Small Molecule
- Groups
- Approved, Investigational, Vet approved
- Structure
Structure for Calcium lactate (DB13231)
- Weight
- Average: 218.218
Monoisotopic: 218.0103289 - Chemical Formula
- C6H10CaO6
- Synonyms
- 2-Hydroxypropanoic acid calcium salt
- Calcio lactato
- Calcium 2-hydroxypropanoate (1:2)
- Calcium dilactate
- Calcium lactate
- Hemicalcium L-lactate
- External IDs
- E-327
- INS NO.327
- INS-327
Pharmacology
- Indication
Indicated for use as the nutritional supplement.
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- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively 4.
- Mechanism of action
In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid. Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways 4. Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis 4.
- Absorption
In order to be absorbed, calcium must be in its freely soluble form (Ca2+) or bound to a soluble organic molecule. Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins 4. The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport 4.
- Volume of distribution
The majority of calcium absorbed (99%) is stored in the skeleton and teeth for structural integrity 4.
- Protein binding
No pharmacokinetic data available.
- Metabolism
In hepatic gluconeogenesis, lactic acid is converted to glucose. Lactic acid may be further catabolyzed in the lactic acid cycle 4.
- Route of elimination
Following oral administration to a human volunteer, 20 to 30% of a dose of lactic acid of up to 3000 mg was excreted via the urine during a period of 14 hours 4.
- Half-life
No pharmacokinetic data available.
- Clearance
No pharmacokinetic data available.
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
The LDLo of calcium lactate pentahydrate following intravenous administration in mouse is 140 mg/kg MSDS.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcebutolol The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium lactate. Acetyldigitoxin Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin. Alendronic acid The serum concentration of Alendronic acid can be decreased when it is combined with Calcium lactate. Alfacalcidol The risk or severity of adverse effects can be increased when Alfacalcidol is combined with Calcium lactate. Atenolol The therapeutic efficacy of Atenolol can be decreased when used in combination with Calcium lactate. Bendroflumethiazide Bendroflumethiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level. Benzthiazide Benzthiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level. Betaxolol The therapeutic efficacy of Betaxolol can be decreased when used in combination with Calcium lactate. Bisoprolol The therapeutic efficacy of Bisoprolol can be decreased when used in combination with Calcium lactate. Calcifediol The risk or severity of adverse effects can be increased when Calcifediol is combined with Calcium lactate. 
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- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Appeton Essentials Milk Calcium Tablet Oral KOTRA PHARMA (M) SDN. BHD. 2020-09-08 Not applicable Malaysia 
CALACTATE 300 TABLET Tablet Oral Hovid Berhad 2020-09-08 Not applicable Malaysia Calcimax Tab 324mg Tablet 324 mg / tab Oral Carmaran LtÉe 1978-12-31 1997-09-15 Canada 
Calcium Lactate 650mg Tablet 120 mg Oral Great Earth Companies, Inc. 1998-08-25 2002-10-02 Canada Calcium Lactate Caps Capsule 100 mg / cap Oral Twin Laboratories Inc. 1995-12-31 1999-11-10 Canada Calcium Lactate Tab 10gr Tablet 650 mg Oral Swiss Herbal Remedies Ltd. 1974-12-31 2009-08-04 Canada Calcium Lactate Tab 324mg Tablet 324 mg / tab Oral Laboratoire Romilo 1980-12-31 1999-08-18 Canada Calcium Lactate Tab 648mg Tablet 648 mg / tab Oral Pharmetics (2011) Inc. 1973-12-31 2000-08-21 Canada Calcium Lactate Tab 648mg Tablet 648 mg Oral Vita Health Products Inc 1983-12-31 2002-07-31 Canada Calcium Lactate Tab 648mg Tablet 648 mg Oral Hall Laboratories, Ltd. 1981-12-31 2003-09-11 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Cal M Tab Calcium lactate (83.33 mg) + Magnesium oxide (66.67 mg) + Niacin (30 mg) + Pyridoxine hydrochloride (15 mg) + Thiamine mononitrate (15 mg) + Vitamin D (133.33 unit) Tablet Oral Anabolic Laboratories Inc. 1978-12-31 2004-03-15 Canada Cal-mag Tablet Calcium lactate (48 mg / tab) + Magnesium citrate (7 mg / tab) Tablet Oral Standard Process Inc. Not applicable Not applicable Canada Calcium Ctr Srt Calcium lactate (200 mg / tab) + Vitamin D (80 unit / tab) Tablet, extended release Oral Bioenergy Inc. 1981-12-31 1998-06-03 Canada Calcium Lactate Et Magnesium Sulfate Calcium lactate (260 mg) + Magnesium sulfate (65 mg) Tablet Oral Bio Vita 1987-12-31 2005-07-20 Canada Calcium Lactate Powder Calcium lactate (119 mg / g) + Magnesium citrate (18 mg / g) Powder Oral Standard Process Inc. Not applicable Not applicable Canada Calcium Magnesium Tablets Nu Life Calcium lactate (115 mg / tab) + Magnesium oxide (70 mg / tab) Tablet Oral Nu Life Nutrition Ltd. 1963-12-31 2000-05-23 Canada Calcium Supplement Tab Calcium lactate (10 mg) + Calcium carbonate (156 mg) + Cholecalciferol (66.6 unit) + Magnesium oxide (66.6 mg) Tablet Oral Hillestad Pharmaceuticals Usa 1997-09-04 2009-09-22 Canada Dicalcine Tab No460 Calcium lactate (155 mg) + Calcium gluconate (155 mg) Tablet Oral Herbes Universelles Inc. 1976-12-31 2009-07-15 Canada FOSFO KALSIYUM GRANULE, 200 G Calcium lactate (200 mg) + Calcium phosphate, tribasic (200 mg) + Calcium gluconate (600 mg) + Cholecalciferol (400 IU) Powder Oral MÜNİR ŞAHİN İLAÇ SAN. VE TİC A.Ş. 2020-08-14 Not applicable Turkey 
FOSFO KALSIYUM GRANULE, 75 G Calcium lactate (200 mg) + Calcium phosphate, tribasic (200 mg) + Calcium gluconate (600 mg) + Cholecalciferol (400 IU) Powder Oral MÜNİR ŞAHİN İLAÇ SAN. VE TİC A.Ş. 2020-08-14 Not applicable Turkey - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Lab52 Anti-Cavity Oral Care Calcium lactate (0.05 g/100g) + Xylitol (12 g/100g) Aerosol Dental TOOTHFILM INC 2022-05-04 Not applicable US 
Lab52 Anti-Sensitivity Oral Care Calcium lactate (0.2 g/100g) + Potassium citrate monohydrate (5.4 g/100g) + Xylitol (10 g/100g) Aerosol Dental TOOTHFILM INC 2022-05-07 Not applicable US Lab52 Kids Oral Protection Calcium lactate (0.05 g/100g) + Xylitol (10 g/100g) Aerosol Dental TOOTHFILM INC 2022-05-04 Not applicable US Lab52 Kids Oral Protection Calcium lactate (0.05 g/100g) + Xylitol (10 g/100g) Aerosol Dental TOOTHFILM INC 2022-05-04 Not applicable US Lab52 Kids Oral Protection Calcium lactate (0.05 g/100g) + Xylitol (10 g/100g) Aerosol Dental TOOTHFILM INC 2022-05-04 Not applicable US
Categories
- ATC Codes
- A12AA05 — Calcium lactate
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as carboxylic acid salts. These are ionic derivatives of carboxylic acid.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Carboxylic acid derivatives
- Direct Parent
- Carboxylic acid salts
- Alternative Parents
- Secondary alcohols / Organic calcium salts / Monocarboxylic acids and derivatives / Carboxylic acids / Organic zwitterions / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Alcohol / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid salt / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic calcium salt / Organic oxide / Organic oxygen compound
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 2URQ2N32W3
- CAS number
- 814-80-2
- InChI Key
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L
- InChI
- InChI=1S/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2
- IUPAC Name
- calcium bis(2-hydroxypropanoate)
- SMILES
- [Ca++].CC(O)C([O-])=O.CC(O)C([O-])=O
References
- General References
- FDA CFR - Code of Federal Regulations Title 21: Sec. 184.1207 Calcium lactate [Link]
- FDA Thailand Product Information: Calion (calcium lactate) oral tablets [Link]
- NPRA: Pri-Calcium (Calcium Lactate) Oral Tablets [Link]
- GRAS Notification for the Use of Calcium Lactate in Potato and Vegetable Snacks and Sweetened Crackers [File]
- External Links
- PubChem Compound
- 13144
- PubChem Substance
- 347829287
- ChemSpider
- 12592
- 47622
- ChEMBL
- CHEMBL2106111
- Wikipedia
- Calcium_lactate
- MSDS
- Download (218 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Completed Prevention Dental Decay 1 1, 2 Unknown Status Treatment Renal Insufficiency,Chronic 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet Oral 324 mg / tab Tablet, extended release Oral Tablet Oral Tablet Oral 120 mg Capsule Oral 100 mg / cap Powder Oral Tablet Oral 650 mg Tablet Oral 648 mg / tab Tablet Oral 648 mg Tablet Oral 650 mg / tab Tablet Oral 84.5 mg / tab Tablet Oral 84 mg Tablet Oral Aerosol Dental Tablet Oral 84.2 mg Tablet Oral 42.1 mg / tab Syrup Oral Tablet, effervescent Tablet Oral 300 mg Tablet - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) > 120 MSDS water solubility 48 g/L MSDS - Predicted Properties
Property Value Source Water Solubility 191.0 mg/mL ALOGPS logP -0.36 ALOGPS logP -0.47 Chemaxon logS -0.06 ALOGPS pKa (Strongest Acidic) 3.78 Chemaxon pKa (Strongest Basic) -3.7 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 60.36 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 29.68 m3·mol-1 Chemaxon Polarizability 7.65 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at June 23, 2017 20:38 / Updated at June 05, 2021 09:13