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Calcium lactate
Identification
- Name
- Calcium lactate
- Accession Number
- DB13231
- Description
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener 1. Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
- Type
- Small Molecule
- Groups
- Approved, Investigational, Vet approved
- Structure
Structure for Calcium lactate (DB13231)
- Weight
- Average: 218.218
Monoisotopic: 218.0103289 - Chemical Formula
- C6H10CaO6
- Synonyms
- 2-Hydroxypropanoic acid calcium salt
- Calcio lactato
- Calcium 2-hydroxypropanoate (1:2)
- Calcium dilactate
- Hemicalcium L-lactate
- External IDs
- E-327
- INS NO.327
- INS-327
Pharmacology
- Indication
Indicated for use as the nutritional supplement.
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively 2.
- Mechanism of action
In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid. Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways 2. Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis 2.
- Absorption
In order to be absorbed, calcium must be in its freely soluble form (Ca2+) or bound to a soluble organic molecule. Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins 2. The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport 2.
- Volume of distribution
The majority of calcium absorbed (99%) is stored in the skeleton and teeth for structural integrity 2.
- Protein binding
No pharmacokinetic data available.
- Metabolism
In hepatic gluconeogenesis, lactic acid is converted to glucose. Lactic acid may be further catabolyzed in the lactic acid cycle 2.
- Route of elimination
Following oral administration to a human volunteer, 20 to 30% of a dose of lactic acid of up to 3000 mg was excreted via the urine during a period of 14 hours 2.
- Half-life
No pharmacokinetic data available.
- Clearance
No pharmacokinetic data available.
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
The LDLo of calcium lactate pentahydrate following intravenous administration in mouse is 140 mg/kg MSDS.
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Unlock Additional DataAcebutolol The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium lactate. Acetyldigitoxin Calcium lactate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin. Alendronic acid The serum concentration of Alendronic acid can be decreased when it is combined with Calcium lactate. Alfacalcidol The risk or severity of adverse effects can be increased when Calcium lactate is combined with Alfacalcidol. Atenolol The therapeutic efficacy of Atenolol can be decreased when used in combination with Calcium lactate. Bendroflumethiazide Bendroflumethiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level. Benzthiazide Benzthiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level. Betaxolol The therapeutic efficacy of Betaxolol can be decreased when used in combination with Calcium lactate. Bisoprolol The therapeutic efficacy of Bisoprolol can be decreased when used in combination with Calcium lactate. Calcifediol The risk or severity of adverse effects can be increased when Calcium lactate is combined with Calcifediol. Additional Data Available- Extended DescriptionExtended Description
Extended description of the mechanism of action and particular properties of each drug interaction.
Learn more - Severity
- Evidence Level
- ActionAction
An effect category for each drug interaction. Know how this interaction affects the subject drug.
Learn more
- Food Interactions
- Not Available
Products
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Unlock Additional DataCalcimax Tab 324mg Tablet Oral Carmaran LtÉe 1978-12-31 1997-09-15 Canada 
Calcium Lactate Tab 10gr Tablet Oral Swiss Herbal Remedies Ltd. 1974-12-31 2009-08-04 Canada Calcium Lactate Tab 324mg Tablet Oral Laboratoire Romilo 1980-12-31 1999-08-18 Canada Calcium Lactate Tab 648mg Tablet Oral Vita Health Products Inc 1983-12-31 2002-07-31 Canada Calcium Lactate Tab 648mg Tablet Oral Pharmetics (2011) Inc. 1973-12-31 2000-08-21 Canada Calcium Lactate Tab 648mg Tablet Oral Hall Laboratories, Ltd. 1981-12-31 2003-09-11 Canada Calcium Lactate Tab 650mg Tablet Oral Vita Health Products Inc 1957-12-31 2002-07-31 Canada Calcium Lactate Tab 650mg Tablet Oral Shoppers Drug Mart Inc. 1978-12-31 1997-08-15 Canada Calcium Lactate Tab 650mg USP Tablet Oral Nobel Pharm Enr. 1988-12-31 1997-07-31 Canada Additional Data Available- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Calcium Ctr Srt Calcium lactate (200 mg) + Vitamin D (80 unit) Tablet, extended release Oral Bioenergy Inc. 1981-12-31 1998-06-03 Canada Calcium Lactate Et Magnesium Sulfate Calcium lactate (260 mg) + Magnesium sulfate (65 mg) Tablet Oral Bio Vita 1987-12-31 2005-07-20 Canada Calcium Supplement Tab Calcium lactate (10 mg) + Calcium carbonate (156 mg) + Cholecalciferol (66.6 unit) + Magnesium oxide (66.6 mg) Tablet Oral Hillestad Pharmaceuticals Usa 1997-09-04 2009-09-22 Canada Dicalcine Tab No460 Calcium lactate (155 mg) + Calcium gluconate (155 mg) Tablet Oral Herbes Universelles Inc. 1976-12-31 2009-07-15 Canada Mangadyn Calcium lactate (175 mg) + Ascorbic acid (80 mg) + Choline bitartrate (30 mg) + Cyanocobalamin (10 mcg) + Manganese sulfate (200 mg) + Pyridoxine (10 mg) + Thiamine (5 mg) + Vitamin E (10 unit) Tablet Oral Nutri Dyn Products Ltd. 1982-12-31 1997-08-22 Canada Pro Enz Tab Calcium lactate (333 mg) + Ascorbic acid (30 mg) + Citrus bioflavonoids (30 mg) + Cyanocobalamin (3 mcg) + Manganese (15.4 mg) + Niacin (10 mg) + Nicotinamide (30 mg) + Zinc (1.95 mg) Tablet Oral Anabolic Laboratories Inc. 1970-12-31 2004-03-15 Canada
Categories
- ATC Codes
- A12AA05 — Calcium lactate
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as carboxylic acid salts. These are ionic derivatives of carboxylic acid.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Carboxylic acid derivatives
- Direct Parent
- Carboxylic acid salts
- Alternative Parents
- Secondary alcohols / Organic calcium salts / Monocarboxylic acids and derivatives / Carboxylic acids / Organic zwitterions / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Alcohol / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid salt / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic calcium salt / Organic oxide / Organic oxygen compound
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
Chemical Identifiers
- UNII
- 2URQ2N32W3
- CAS number
- 814-80-2
- InChI Key
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L
- InChI
- InChI=1S/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2
- IUPAC Name
- calcium bis(2-hydroxypropanoate)
- SMILES
- [Ca++].CC(O)C([O-])=O.CC(O)C([O-])=O
References
- General References
- External Links
- PubChem Compound
- 13144
- PubChem Substance
- 347829287
- ChemSpider
- 12592
- 47622
- ChEMBL
- CHEMBL2106111
- Wikipedia
- Calcium_lactate
- MSDS
- Download (218 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Completed Prevention Dental Decay 1 1, 2 Unknown Status Treatment Renal Insufficiency,Chronic 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, extended release Oral Tablet Oral Powder Oral 600 mg Tablet Oral Tablet - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) > 120 MSDS water solubility 48 g/L MSDS - Predicted Properties
Property Value Source Water Solubility 191.0 mg/mL ALOGPS logP -0.36 ALOGPS logP -0.47 ChemAxon logS -0.06 ALOGPS pKa (Strongest Acidic) 3.78 ChemAxon pKa (Strongest Basic) -3.7 ChemAxon Physiological Charge -1 ChemAxon Hydrogen Acceptor Count 3 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 60.36 Å2 ChemAxon Rotatable Bond Count 2 ChemAxon Refractivity 29.68 m3·mol-1 ChemAxon Polarizability 7.65 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created on June 23, 2017 14:38 / Updated on June 12, 2020 10:53
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