NAV

Calcium lactate

Identification

Name
Calcium lactate
Accession Number
DB13231
Description

Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener 1. Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.

Type
Small Molecule
Groups
Approved, Investigational, Vet approved
Structure
Thumb
Similar Structures
Weight
Average: 218.218
Monoisotopic: 218.0103289
Chemical Formula
C6H10CaO6
Synonyms
  • 2-Hydroxypropanoic acid calcium salt
  • Calcio lactato
  • Calcium 2-hydroxypropanoate (1:2)
  • Calcium dilactate
  • Calcium lactate
  • Hemicalcium L-lactate
External IDs
  • E-327
  • INS NO.327
  • INS-327

Pharmacology

Pharmacology
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Indication

Indicated for use as the nutritional supplement.

Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively 3.

Mechanism of action

In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid. Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways 3. Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis 3.

Absorption

In order to be absorbed, calcium must be in its freely soluble form (Ca2+) or bound to a soluble organic molecule. Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins 3. The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport 3.

Volume of distribution

The majority of calcium absorbed (99%) is stored in the skeleton and teeth for structural integrity 3.

Protein binding

No pharmacokinetic data available.

Metabolism

In hepatic gluconeogenesis, lactic acid is converted to glucose. Lactic acid may be further catabolyzed in the lactic acid cycle 3.

Route of elimination

Following oral administration to a human volunteer, 20 to 30% of a dose of lactic acid of up to 3000 mg was excreted via the urine during a period of 14 hours 3.

Half-life

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Adverse Effects
Medicalerrors
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Toxicity

The LDLo of calcium lactate pentahydrate following intravenous administration in mouse is 140 mg/kg MSDS.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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AcebutololThe therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium lactate.
AcetyldigitoxinCalcium lactate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium lactate.
AlfacalcidolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Alfacalcidol.
AtenololThe therapeutic efficacy of Atenolol can be decreased when used in combination with Calcium lactate.
BendroflumethiazideBendroflumethiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
BenzthiazideBenzthiazide may decrease the excretion rate of Calcium lactate which could result in a higher serum level.
BetaxololThe therapeutic efficacy of Betaxolol can be decreased when used in combination with Calcium lactate.
BisoprololThe therapeutic efficacy of Bisoprolol can be decreased when used in combination with Calcium lactate.
CalcifediolThe risk or severity of adverse effects can be increased when Calcium lactate is combined with Calcifediol.
Interactions
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Food Interactions
Not Available

Products

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Calcimax Tab 324mgTabletOralCarmaran LtÉe1978-12-311997-09-15Canada flag
Calcium Lactate Tab 10grTabletOralSwiss Herbal Remedies Ltd.1974-12-312009-08-04Canada flag
Calcium Lactate Tab 324mgTabletOralLaboratoire Romilo1980-12-311999-08-18Canada flag
Calcium Lactate Tab 648mgTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada flag
Calcium Lactate Tab 648mgTabletOralPharmetics (2011) Inc.1973-12-312000-08-21Canada flag
Calcium Lactate Tab 648mgTabletOralVita Health Products Inc1983-12-312002-07-31Canada flag
Calcium Lactate Tab 650mgTabletOralShoppers Drug Mart Inc.1978-12-311997-08-15Canada flag
Calcium Lactate Tab 650mgTabletOralVita Health Products Inc1957-12-312002-07-31Canada flag
Calcium Lactate Tab 650mg USPTabletOralNobel Pharm Enr.1988-12-311997-07-31Canada flag
คาลิอ้อนTablet300 mgOralบริษัท อเมริกันบริติช จำกัด จำกัด1986-08-18Not applicableThailand flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Calcium Ctr SrtCalcium lactate (200 mg) + Vitamin D (80 unit)Tablet, extended releaseOralBioenergy Inc.1981-12-311998-06-03Canada flag
Calcium Lactate Et Magnesium SulfateCalcium lactate (260 mg) + Magnesium sulfate (65 mg)TabletOralBio Vita1987-12-312005-07-20Canada flag
Calcium Supplement TabCalcium lactate (10 mg) + Calcium carbonate (156 mg) + Cholecalciferol (66.6 unit) + Magnesium oxide (66.6 mg)TabletOralHillestad Pharmaceuticals Usa1997-09-042009-09-22Canada flag
Dicalcine Tab No460Calcium lactate (155 mg) + Calcium gluconate (155 mg)TabletOralHerbes Universelles Inc.1976-12-312009-07-15Canada flag
MangadynCalcium lactate (175 mg) + Ascorbic acid (80 mg) + Choline bitartrate (30 mg) + Cyanocobalamin (10 mcg) + Manganese sulfate (200 mg) + Pyridoxine (10 mg) + Thiamine (5 mg) + Vitamin E (10 unit)TabletOralNutri Dyn Products Ltd.1982-12-311997-08-22Canada flag
Pro Enz TabCalcium lactate (333 mg) + Ascorbic acid (30 mg) + Citrus bioflavonoids (30 mg) + Cyanocobalamin (3 mcg) + Manganese (15.4 mg) + Niacin (10 mg) + Nicotinamide (30 mg) + Zinc (1.95 mg)TabletOralAnabolic Laboratories Inc.1970-12-312004-03-15Canada flag
แคล - ฟอร์ทCalcium lactate (2.93 G) + Calcium carbonate (300 MG) + Calcium gluconate (10 MG)Tablet, effervescentบริษัท บี.เอ็ล.ฮั้ว จำกัด จำกัด2004-09-13Not applicableThailand flag
แคล - ฟอร์ทCalcium lactate (2.93 G) + Calcium carbonate (300 MG) + Calcium gluconate (10 MG)Tablet, effervescentบริษัท บี.เอ็ล.ฮั้ว จำกัด จำกัด2004-09-13Not applicableThailand flag
แคล-ฟอร์ทCalcium lactate (2.93 G) + Calcium carbonate (300 MG) + Calcium gluconate (10 MG)Tablet, effervescentบริษัท บี.เอ็ล.ฮั้ว จำกัด จำกัด2007-01-31Not applicableThailand flag
แคลลิมอน ชนิดเม็ดฟู่Calcium lactate (400 MG) + Ascorbic acid (1 G) + Calcium carbonate (457 MG)Tablet, effervescentบริษัท นีโอ ฟาร์ม จำกัด จำกัด2004-08-082019-10-21Thailand flag

Categories

ATC Codes
A12AA05 — Calcium lactate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as carboxylic acid salts. These are ionic derivatives of carboxylic acid.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Carboxylic acid derivatives
Direct Parent
Carboxylic acid salts
Alternative Parents
Secondary alcohols / Organic calcium salts / Monocarboxylic acids and derivatives / Carboxylic acids / Organic zwitterions / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Alcohol / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid salt / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic calcium salt / Organic oxide / Organic oxygen compound
Molecular Framework
Not Available
External Descriptors
Not Available

Chemical Identifiers

UNII
2URQ2N32W3
CAS number
814-80-2
InChI Key
MKJXYGKVIBWPFZ-UHFFFAOYSA-L
InChI
InChI=1S/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2
IUPAC Name
calcium bis(2-hydroxypropanoate)
SMILES
[Ca++].CC(O)C([O-])=O.CC(O)C([O-])=O

References

General References
  1. FDA CFR - Code of Federal Regulations Title 21: Sec. 184.1207 Calcium lactate [Link]
  2. FDA Thailand Product Information: Calion (calcium lactate) oral tablets [Link]
  3. GRAS Notification for the Use of Calcium Lactate in Potato and Vegetable Snacks and Sweetened Crackers [File]
PubChem Compound
13144
PubChem Substance
347829287
ChemSpider
12592
RxNav
47622
ChEMBL
CHEMBL2106111
Wikipedia
Calcium_lactate
MSDS
Download (218 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedPreventionDental Decay1
1, 2Unknown StatusTreatmentRenal Insufficiency,Chronic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, extended releaseOral
TabletOral500 MG
TabletOral
TabletOral0.1 mg
PowderOral600 mg
TabletOral
SyrupOral1.25 mcg
TabletOral300 MG
TabletOral10 mcg
Tablet, effervescent
Tablet
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)> 120MSDS
water solubility48 g/LMSDS
Predicted Properties
PropertyValueSource
Water Solubility191.0 mg/mLALOGPS
logP-0.36ALOGPS
logP-0.47ChemAxon
logS-0.06ALOGPS
pKa (Strongest Acidic)3.78ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.36 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity29.68 m3·mol-1ChemAxon
Polarizability7.65 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on June 23, 2017 20:38 / Updated on February 21, 2021 18:54