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Natamycin
go.drugbank.com/drugs/DB00826ApprovedInvestigationalAmphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. [PubChem]
Categories: Alimentary Tract and Metabolism, Genito Urinary System and Sex HormonesSipuleucel-T
go.drugbank.com/drugs/DB06688ApprovedInvestigationalSipuleucel-T was approved by the U.S. Food and Drug Administration (FDA) on April 29, 2010, to treat asymptomatic or minimally symptomatic metastatic Hormone-Refractory Prostate Cancer (HRPC). … The treatment initially cost $93,000 at the time of FDA approval, but rose to over $100,000 in 2014.
Categories: Antineoplastic and Immunomodulating AgentsTrifarotene
go.drugbank.com/drugs/DB12808ApprovedInvestigationalas compared to older, less selective retinoids. … to vitamin A and are analogous only in function.
Categories: Skin and Mucous Membrane AgentsDrospirenone
go.drugbank.com/drugs/DB01395ApprovedInvestigational[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and premenstrual dysphoric disorder (PMDD). … [L7973] Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy.
Mixtures: Drospirenone and Ethinyl Estradiol, Drospirenone and Ethinyl EstradiolCategories: drospirenone and estetrol, drospirenone and estrogenTriamterene
go.drugbank.com/drugs/DB00384ApprovedTriamterene is a weak antagonist of folic acid, and a photosensitizing drug.[L6163] Triamterene was approved by the Food and Drug Administration in the U.S. in 1964. … It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side.
Mixtures: Riva-zide 50/25mg Tablets, TRI THIAZID STADA 50/25MGCategories: Decreased Renal K+ ExcretionChlormerodrin
go.drugbank.com/drugs/DB00534ApprovedWithdrawnThe radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.
Prostatic Hypertrophy
go.drugbank.com/conditions/DBCOND0079911Drugs: Pygeum africanum barkSynonyms: Glandular, stromal and muscular hyperplasia of prostate gland, Glandular, stromal AND/OR muscular hyperplasia of prostate glandLoncastuximab tesirine
go.drugbank.com/drugs/DB16222ApprovedInvestigational[L45206] This therapy was developed by ADC Therapeutics and its accelerated approval for relapsed or refractory B-cell lymphoma is based on promising results from the LOTIS-2 clinical trial. … [A234439] Prognosis is poor and more effective therapies are needed to treat relapsed/refractory cases and improve survival.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsBronopol
go.drugbank.com/drugs/DB13960ApprovedFirst synthesized in 1897, bronopol was primarily used as a preservative for pharmaceuticals and was registered in the United States in 1984 for use in industrial bactericides, slimicides and preservatives … systems, papermills, absorbent clays, metal working fluids, printing inks, paints, adhesives and consumer products [F13].
Mixtures: Antiseptic Hand Soap, Hand Sanitizing WipesCategories: Indicators and ReagentsArtemether
go.drugbank.com/drugs/DB06697ApprovedInvestigational</i> and may be used to treat infections caused by <i>P. falciparum</i> and unidentified <i>Plasmodium</i> species, including infections acquired in chloroquine-resistant areas. … Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy.
Mixtures: COARTEM® TABLETAS DISPERSABLES 20/120MGCategories: Artemisinin and derivatives, artemether and lumefantrine