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Pegvaliase
go.drugbank.com/drugs/DB12839ApprovedInvestigational[L42725] It is advantageous over currently available management therapies for PKU, such as [DB00360], that are ineffective to many patients due to long-term adherence issues or inadequate Phe-lowering … Phenylketonuria is a rare autosomal recessive disorder that is characterized by deficiency of the enzyme phenylalanine hydroxylase (PAH) [A33284] and affects about 1 in 10,000 to 15,000 people in the United
Bromothalonil
go.drugbank.com/drugs/DB14199ApprovedIn 2005, MDBGN was named in the top 15 most frequently positive allergens identified in patch tests by the North American Contact Dermatitis Group (NACDG)[A34326]. … It is also a known allergen and dermatological irritant that has been banned in many EU countries due to increasing rates of contact allergy [A34322].
Categories: Compounds used in a research, industrial, or household settingSargramostim
go.drugbank.com/drugs/DB00020ApprovedInvestigationalSargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues.
Levacetylmethadol
go.drugbank.com/drugs/DB01227ApprovedWithdrawnIt is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. … The production of levacetylmethadol in the US has ceased as well.[L44052,T862]
Categories: Drugs Used in Opioid Dependence, Drugs Used in Addictive DisordersKD7040
go.drugbank.com/drugs/DB05214InvestigationalThe KD7040 IND was filed in 4Q06, and a Phase Ib clinical trial began 2Q07. It is being developed by Kalypsys.
Belinostat
go.drugbank.com/drugs/DB05015ApprovedInvestigationalThe safety and efficacy of belinostat is currently being evaluated for use in combination with traditional front-line therapies for the treatment of PTCL. … It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget.
Synonyms: (2E)-N-HYDROXY-3-(3-(PHENYLSULFAMOYL)PHENYL)PROP-2-ENAMIDE, N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamideGelatin
go.drugbank.com/drugs/DB11242ApprovedInvestigationalVet approvedWithdrawnGelatin is a multifunctional ingredient that is used in foods, pharmaceuticals, cosmetics, and photographic films as a gelling agent, stabilizer, thickener, emulsifier, as well as film former. … [A32432] Interestingly, horse gelatin has been studied and it was found that in the horse, gelatin influences the homeostasis of the amino acids required for cartilage synthesis [A32434].
Mixtures: Gelofusin Iso 40 mg/ml Infusionslösung, GELOFUSINE ENFÜZYON, 500 ML SETLİProducts: INFUSOL SG (SUCCINYLATED GELATIN (Bovine) INTRAVENOUS INFUSION 4% w/v)Ertugliflozin
go.drugbank.com/drugs/DB11827ApprovedInvestigational[A31581] Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018.[L48621]
Mixtures: สเตกกลูแจน (15 มิลลิกรัม/100 มิลลิกรัม), สเตกกลูแจน (15 มิลลิกรัม/100 มิลลิกรัม)Categories: Drugs Used in DiabetesPolatuzumab vedotin
go.drugbank.com/drugs/DB12240ApprovedInvestigational[L6658] Polatuzumab vedotin was granted accelerated FDA approval on June 10, 2019 [A254936] and was approved by Health Canada on July 9, 2020.[L44141] … Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells.
Avapritinib
go.drugbank.com/drugs/DB15233ApprovedInvestigationalAvapritinib was granted FDA approval on 9 January 2020 [L40363] and EMA approval on 24 September 2020.[L41464]