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Displaying results 231 - 240 of 1186 in total
  1. Target

    Sigma receptor

    go.drugbank.com/bio_entities/BE0004897
    TargetHumans

    Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021)

    Polypeptides: Sigma non-opioid intracellular receptor 1, Membrane-associated progesterone receptor component 1Synonyms: Sigma1-receptor, Sigma 1-type opioid receptor
  2. Target

    Estrogen receptor

    go.drugbank.com/bio_entities/BE0010245
    TargetHumans

    Nuclear hormone receptor. … Nuclear hormone receptor.

    Polypeptides: Estrogen receptor, Estrogen receptor betaSynonyms: Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
  3. Target

    Somatostatin receptor

    go.drugbank.com/bio_entities/BE0010250
    TargetHumans

    Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. … Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

    Polypeptides: Somatostatin receptor type 1, Somatostatin receptor type 2Function: G protein-coupled receptor activity
  4. Target

    Cannabinoid receptor

    go.drugbank.com/bio_entities/BE0010258
    TargetHumans

    Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. … G protein-coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such

    Polypeptides: Cannabinoid receptor 1, Cannabinoid receptor 2Function: cannabinoid receptor activity, cannabinoid receptor activity
  5. Target

    Folate receptor

    go.drugbank.com/bio_entities/BE0010260
    TransporterTargetHumans

    Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release … Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728).

    Polypeptides: Folate receptor alpha, Folate receptor betaSynonyms: Folate receptor 1, Folate receptor 2
  6. Target

    Adenosine receptor

    go.drugbank.com/bio_entities/BE0010284
    TargetHumans

    Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase … Receptor for adenosine (PubMed:29925945). The activity of this receptor is mediated by G proteins such as GNAI2 which inhibit adenylyl cyclase

    Polypeptides: Adenosine receptor A1, Adenosine receptor A2aFunction: G protein-coupled adenosine receptor activity, G protein-coupled adenosine receptor activity
  7. Target

    Apelin receptor

    go.drugbank.com/bio_entities/BE0013166
    TargetHumans

    G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis … When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor (PubMed:11090199

    Polypeptides: Apelin receptorSynonyms: Angiotensin receptor-like 1, G protein-coupled receptor APJ
  8. Drug

    Acetazolamide

    go.drugbank.com/drugs/DB00819
    ApprovedInvestigationalVet approved

    One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizur...

  9. Indication

    Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma

    go.drugbank.com/conditions/DBCOND0162925
    Drugs: Sacituzumab govitecan
    Synonyms: Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma, Unresectable, locally advanced Hormone Receptor Positive Breast Carcinoma
  10. Drug

    Drotaverine

    go.drugbank.com/drugs/DB06751
    ApprovedWithdrawn

    Drotaverine is an antispasmodic drug that works by inhibiting phosphodiesterase-4 (PDE4). It is a benzylisoquinoline derivative that is structurally related to papaverine, although it displays more potent antispasmodic activities than pa...