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Fecal microbiota
go.drugbank.com/drugs/DB17743ApprovedInvestigationalRecurrent CDI has a high risk of mortality and a high failure rate. … Fecal microbiota, given either as a rectal transplant or in an oral formulation of live spores, is an FDA-approved option to prevent the recurrence of _Clostridioides difficile_ infection (CDI) in patients
Alitretinoin
go.drugbank.com/drugs/DB00523ApprovedTretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. … An important regulator of gene expression during growth and development, and in neoplasms.
Categories: Vitamin A, P-glycoprotein substratesRemestemcel-L
go.drugbank.com/drugs/DB13973ApprovedInvestigationalWithdrawnwith first-line therapies, putting them in a risk for poor outcomes and creating a significant clinical challenge [A31818]. … In clinical studies, patients treated with remestemcel-L demonstrated an improvement in their aGvHD and improved survival rates at subsequent days following intravenous infusion [L11022].
Lutetium Lu 177 dotatate
go.drugbank.com/drugs/DB13985ApprovedInvestigationalA 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with … Lutetium Lu 177 dotatate may also be referred to as 177Lu-DOTA-Tyr3-octreotate.
Categories: Compounds used in a research, industrial, or household settingProbenecid
go.drugbank.com/drugs/DB01032ApprovedInvestigationalProbenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 CYP2C8 InducersSynonyms: p-(Dipropylsulfamoyl)benzoic acidNV-07a
go.drugbank.com/drugs/DB05845ExperimentalNV-07a is topical skin repair compound protecting skin from sun-induced immunosuppression and UV-induced damage.
Imiquimod
go.drugbank.com/drugs/DB00724ApprovedInvestigationalImiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. … Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain types of skin cancer called superficial basal cell carcinoma.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Aldara PTarlatamab
go.drugbank.com/drugs/DB17256ApprovedInvestigational[L50748] It is a bispecific monoclonal antibody that targets CD3 expressed on the surface of T-cells and delta-like ligand 3 (DLL3), an inhibitory ligand that suppresses Notch signaling and is highly expressed … Tarlatamab is a first-in-class T-cell engager used to treat extensive-stage small cell lung cancer.
Bendroflumethiazide
go.drugbank.com/drugs/DB00436ApprovedInvestigationalA thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders.