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Abiraterone
go.drugbank.com/drugs/DB05812ApprovedInvestigationalAbiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis … It is used to treat metastatic castration-resistant prostate cancer, hormone-sensitive high-risk metastatic prostate cancer.
Categories: Metabolic Side Effects of Drugs and Substances, P-glycoprotein inhibitorsSynonyms: (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, 17-(3-Pyridyl)androsta-5,16-dien-3beta-olGimeracil
go.drugbank.com/drugs/DB09257ApprovedInvestigationalApproved by the European Medicines Agency (EMA) in March 2011, Gimeracil is available in combination with [DB03209] and [DB09256] within the commercially available product "Teysuno". … The main active ingredient in Teysuno is [DB09256], a pro-drug of [DB00544] (5-FU), which is a cytotoxic anti-metabolite drug that acts on rapidly dividing cancer cells.
Mixtures: TS-ONE OD Tablet 20, TS-ONE OD Tablet 25Categories: Heterocyclic Compounds, 1-RingStreptococcus pneumoniae type 3 capsular polysaccharide antigen
go.drugbank.com/drugs/DB10321ApprovedInvestigationalIt is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia. … Streptococcus pneumoniae type 3 capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 3 of *Streptococcus pneumoniae*.
Mixtures: PNEUMOVAX 23 Injektionslösung in einer Fertigspritze, PNEUMOVAX 23 Injektionslösung in einer DurchstechflascheSynonyms: pneumococcal capsular polysaccharide type 3 vaccine, Streptococcus pneumoniae type 3 capsular polysaccharide antigenSarecycline
go.drugbank.com/drugs/DB12035ApprovedInvestigationalSubsequently, while a number of first line tetracycline therapies like doxycycline and minocycline do exist for treating acne vulgaris, sarecycline presents a new and innovative therapy choice because … After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe facial acne vulgaris [A39993, A39994] the US Food and Drug Administration approved
Categories: combinations of tetracyclines, P-glycoprotein inhibitorsPretomanid
go.drugbank.com/drugs/DB05154ApprovedInvestigationalResearch in recent years has been geared toward the development of novel therapies that target persistent forms of this disease, which have shown resistance to standard therapy regimens. … Persistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality and a cause for significant concern.
Categories: Drugs for Treatment of Tuberculosis, Cytochrome P-450 SubstratesEluxadoline
go.drugbank.com/drugs/DB09272ApprovedInvestigationalof both pain and diarrhea characteristic of IBS-D. … Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D).
Synonyms: 5-({(4-carbamoyl-2,6-dimethyl-L-phenylalanyl)[(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino}methyl)-2-methoxybenzoic acidCategories: Miscellaneous GI Drugs, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeIoxaglic acid
go.drugbank.com/drugs/DB09313ApprovedWithdrawnLike other organic iodine compounds, ioxaglic acid blocks x-rays and is opaque in its appearance on x-ray film, improving the visualization of important structures and organs during angiography, arteriography … Ioxaglic acid is marketed as Hexabrix. This drug is an ionic tri-iodinated benzoate used as a low-osmolality contrast agent during diagnostic imaging procedures.
Categories: Compounds used in a research, industrial, or household setting, Diagnostic Uses of ChemicalsTrovafloxacin
go.drugbank.com/drugs/DB00685ApprovedWithdrawnIt exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. … It was shown to be more effective against Gram-positive bacteria than Gram-negative bacteria when compared to previous fluoroquinolones.
Categories: Topoisomerase II Inhibitors, 4-QuinolonesMethylcellulose
go.drugbank.com/drugs/DB11228ApprovedInvestigationalMethyl cellulose is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel. … The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum of 3, however more typical values
Categories: Compounds used in a research, industrial, or household settingProducts: Murocel Liq 1%Genistein
go.drugbank.com/drugs/DB01645InvestigationalExperimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. Additionally, genistein has antihelmintic activity. … It has been determined to be the active ingredient in <I>Felmingia vestita</I>, which is a plant traditionally used against worms.
Synonyms: 4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)-, 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-oneMixtures: CALCIDAY G 1200 MG/800 IU/50 MG EFERVESAN TABLET, 45 ADET, CALCİDAY G 1000 MG/880 IU/50 MG EFERVESAN TABLET, 40 ADET