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Displaying results 2541 - 2550 of 10000 in total
  1. Drug

    Valproic acid

    go.drugbank.com/drugs/DB00313
    ApprovedInvestigational

    [A178051] It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. … Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton.

    Mixtures: PROKSIVAL XR 300 MG UZUN ETKILI FILM TABLET, 50 ADET, PROKSIVAL XR 300 MG UZUN ETKILI FILM TABLET, 50 ADETCategories: Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index
  2. Drug

    Carglumic acid

    go.drugbank.com/drugs/DB06775
    ApprovedInvestigational

    Food and Drug Administration (FDA) on 18 March 2010. … Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase.

    Categories: Carbamoyl Phosphate Synthetase 1 Activator, Carbamoyl Phosphate Synthetase 1 ActivatorsSynonyms: (S)-2-ureidopentanedioic acid, N-Carbamyl-L-glutamate
  3. Drug

    Levosalbutamol

    go.drugbank.com/drugs/DB13139
    Approved

    Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). … The enantioselective disposition of salbutamol and the possibility that (S)-salbutamol has adverse effects have led to the development of an enantiomerically pure (R)-salbutamol formulation known as levosalbutamol

    Mixtures: İPRALEV 20 MCG/50 MCG AEROSOL İNHALASYONU,SÜSPANSİYON, 200 DOZCategories: Adrenergic beta-2 Receptor Agonists, Cytochrome P-450 CYP3A Inhibitors
  4. Drug

    PXL-770 free acid anhydrous

    go.drugbank.com/drugs/DB17615
    Experimental

    Synonyms: 2-chloro-3-(1-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-6-oxo- 5-phenyl-6,7-dihydrothieno(2, 3-b)pyridin-4-olateCategories: Heterocyclic Compounds, 1-Ring
  5. Drug

    Citalopram

    go.drugbank.com/drugs/DB00215
    ApprovedInvestigational

    It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs. … [A261316] Citalopram was approved by the FDA in 1998 for the treatment of depression in adults 18 years or older.[L5230]

    Mixtures: Sentralopram AM-10Categories: Serotonin 5-HT2 Receptor Antagonists, P-glycoprotein inhibitors
  6. Drug

    Ethiodized oil

    go.drugbank.com/drugs/DB00965
    ApprovedInvestigational

    And although these esters are primarily as ethyl monoiodostearate and ethyl diiodostearate, the actual, specific structure is unknown. … Ethiodized oil is used by injection as a radio-opaque contrast agent. The composition of the oil is comprised of iodine combined with ethyl esters of fatty acids of poppyseed oil.

    Categories: X-Ray Contrast Activity, X-Ray Contrast Media, IodinatedProducts: LİPİODUL ULTRA-FLUİD 480 MG/10 ML ENJEKSİYONLUK ÇÖZELTİ , 5 ML, LİPİODUL ULTRA-FLUİD 480 MG/10 ML ENJEKSİYONLUK ÇÖZELTİ, 10 ML
  7. Drug

    Batoprotafib

    go.drugbank.com/drugs/DB19137
    Investigational

    Batoprotafib is under investigation in clinical trial NCT04330664 (Adagrasib in Combination With TNO155 in Patients With Cancer (KRYSTAL 2)).

    Synonyms: (3s,4s)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)sulfanyl)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro(4.5)decan-4-amine
  8. Drug

    Atorvastatin

    go.drugbank.com/drugs/DB01076
    ApprovedInvestigational

    [A181087, A181406] Some evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within five years) statin use leads to a 20%-22% relative reduction in … More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid.

    Mixtures: Triveram 10 mg/5 mg/5 mg Filmtabletten, TRIVERAM FILM-COATED TABLET 10 mg/5 mg/5 mgCategories: Heterocyclic Compounds, 1-Ring, atorvastatin and ezetimibe
  9. Drug

    Selegiline

    go.drugbank.com/drugs/DB01037
    ApprovedInvestigationalVet approved

    A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. … It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability.

    Synonyms: L-DeprenalinCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  10. Drug

    Pravastatin

    go.drugbank.com/drugs/DB00175
    ApprovedInvestigational

    It was the first statin administered as the active form and not as a prodrug.[T274] This drug was developed by Sankyo Co. … The manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation with _Streptomyces carbophilus_ to introduce the allylic 6-alcohol group.[T239]

    Mixtures: PRAVAFEN® CAPSULASCategories: P-glycoprotein substrates, pravastatin and ezetimibe