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Ezogabine
go.drugbank.com/drugs/DB04953ApprovedWithdrawnIt is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures
Synonyms: Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilateFavipiravir
go.drugbank.com/drugs/DB12466ApprovedInvestigational[A191688,A191772,A191775] Not only does favipiravir inhibit replication of influenza A and B, but the drug has shown promise in the treatment of avian influenza, and may be an alternative option for
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP2C8 InhibitorsInsulin icodec
go.drugbank.com/drugs/DB16693ApprovedInvestigationalInsulin icodec is an ultra long-acting basal insulin analogue. … [L51078]The US FDA subsequently approved insulin icodec in March 2026 for use as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. [L56102]
Aldesleukin
go.drugbank.com/drugs/DB00041ApprovedInvestigationalAldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene.
Categories: Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 CYP3A InhibitorsProducts: PROLEUKIN 18X106 IU/ML STERİL IV LİYOFİLİZE TOZ İÇEREN FLAKON, 1 ADETAllogeneic processed thymus tissue
go.drugbank.com/drugs/DB16736ApprovedAllogeneic processed thymus tissue is used for immune reconstitution in immune disorders where the patients are severely immunocompromised due to the absence of a functional thymus, such as congenital … As part of the immune system, the thymus is an organ responsible for the maturation and selection of T cells [A239814]; thus, patients without a functional thymus experience profound immunodeficiency and
Ergoloid mesylate
go.drugbank.com/drugs/DB01049ApprovedErgoloid Mesylate is an equiproportional preparation of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and dihydroergocryptine.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesTalazoparib
go.drugbank.com/drugs/DB11760ApprovedInvestigationalTalazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair.
Categories: P-glycoprotein substrates, P-glycoprotein substrates with a Narrow Therapeutic IndexEslicarbazepine acetate
go.drugbank.com/drugs/DB09119ApprovedInvestigationalEslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled … activity by inhibiting repeated neuronal firing and stabilizing the inactivated state of voltage-gated sodium channels, thus preventing their return to the activated state during which seizure activity can
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersPrenylamine
go.drugbank.com/drugs/DB04825ApprovedWithdrawnPrenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.
Synonyms: DL-prenylamineCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDitiocarb zinc
go.drugbank.com/drugs/DB14193ApprovedDitiocarb zinc, also known as Diethyldithiocarbamic acid zinc salt, is a known chelator for copper and zinc. It also a dermatological sensitizer and allergen. Sensitivity to ditiocarb zinc may be identified with a clinical patch test.
Categories: Cytochrome P-450 CYP2A6 Inhibitors, Cytochrome P-450 CYP2E1 Inhibitors