Search
Danicopan
go.drugbank.com/drugs/DB15401ApprovedInvestigational[A263501,L50411] Danicopan is a small molecule complement factor D inhibitor that selectively blocks the alternative pathway, thereby working to address extravascular hemolysis when used in conjunction … [L50381] It was first approved in January 2024 in Japan for patients with PNH,[A263506,L50416] shortly after which the EMA adopted a positive opinion and recommended granting it marketing authorization
Categories: P-glycoprotein inhibitors, Complement Factor D InhibitorSynonyms: (2S,4R)-1-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide, (2S,4R)-1-(2-(3-acetyl-5-(2-methylpyrimidine-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridine-2-yl)-4-fluoropyrrolidine-2-carboxamideBethanechol
go.drugbank.com/drugs/DB01019ApprovedAn advantage of bethanechol is that in contrast to acetylcholine, bethanechol is not degraded by cholinesterase allowing its effects to be longer-lasting.[L32539] … [A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous
Synonyms: 2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminium, carbamyl-β-methylcholineProducts: ยูโคลีน (5 มิลลิกรัม)Lodoxamide
go.drugbank.com/drugs/DB06794ApprovedLodoxamide is a mast-cell stabilizer for topical administration into the eye. … Lodoxamide is marketed under the brand name Alomide by Alcon.
Synonyms: N,N'-(2-chloro-5-cyano-m-phenylene)dioxamateProducts: THILOMIDE GÖZ DAMLASI, 5 ML, ALOMİDE % 0.1 GÖZ DAMLASI, ÇÖZELTİ, 5 MLFosnetupitant
go.drugbank.com/drugs/DB14019ApprovedInvestigationalFosnetupitant is the pro-drug form of netupitant [FDA label]. … Generally, 25% to 30% of patients with a diagnosis of cancer receive chemotherapy as a treatment modality and 70% to 80% of these patients undergoing chemotherapy treatment may experience nausea and vomiting
Categories: Substance P/Neurokinin-1 Receptor Antagonist, Cytochrome P-450 CYP3A InhibitorsBelantamab mafodotin
go.drugbank.com/drugs/DB15719ApprovedInvestigationalWithdrawnBelantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). … [L53673] Later that year in October of 2025, belantamab was granded full approval by the FDA for the a similar indication to the Health Canada one. [L54331]
Categories: P-glycoprotein substratesRavulizumab
go.drugbank.com/drugs/DB11580ApprovedInvestigational[A244465] It was later approved by the European Commission on July 2, 2019, for the same indications.[L39710] Ravulizumab is also used to treat myasthenia gravis. … Ravulizumab is a potent and selective complement 5 (C5) inhibitor. It is a humanized monoclonal IgG2/4 kappa antibody produced in Chinese hamster ovary (CHO) cells.
Products: ULTOMIRIS ®, Ultomiris 300 mg/3 mL İnfüzyonluk Çözelti Hazırlamak İçin Konsantre (1 adet)Insulin detemir
go.drugbank.com/drugs/DB01307ApprovedInvestigational[A2358, A2359, A2360, A44] Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal … Insulin detemir is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersProducts: Levemir® FlexPen® 100 U/ml Solution for Injection in Pre-filled Pen, 100 U/MLEnfortumab vedotin
go.drugbank.com/drugs/DB13007ApprovedInvestigational[L10836] Enfortumab vedotin was later approved by the European Commission on April 13, 2022.[L42000] … [L10836] It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protease-cleavable
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: PADCEV 20 MG İNFÜZYONLUK ÇÖZELTİ HAZIRLAMADA KULLANILACAK KONSANTRE İÇİN TOZ , 1 ADET, PADCEV 30 MG İNFÜZYONLUK ÇÖZELTİ HAZIRLAMADA KULLANILACAK KONSANTRE İÇİN TOZ , 1 ADETNilutamide
go.drugbank.com/drugs/DB00665ApprovedInvestigationalProstate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration. … Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: 5,5-Dimethyl-3-(α,α,α-trifluoro-4-nitro-m-tolyl)hydantoinEthotoin
go.drugbank.com/drugs/DB00754ApprovedThe mechanism of action is probably very similar to that of phenytoin. … Ethotoin is no longer commonly used.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersSynonyms: (±)-3-ethyl-5-phenylhydantoin, 3-ethyl-5-phenylhydantoin