Ethotoin is a hydantoin antiepileptic used to control tonic-clonic and complex partial seizures. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression.
- Mechanism
- Curator reviewed
The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin inhibits nerve impulses in the motor cortex by lowering sodium ion influx, limiting tetanic stimulation.
- Primary indication
- For the control of tonic-clonic (grand mal) and complex partial (psychomotor) seizures.Curator reviewed · 2 structured indications
- Formula / weight
- C11H12N2O2 · 204.2252 g/mol (avg)
- First approval
- United States, 1957
- Brand names
Resolves to
SZQIFWWUIBRPBZ-UHFFFAOYSA-NSMILESCCN1C(=O)NC(C1=O)C1=CC=CC=C1What you can answer from here — as of September 13, 2026
Which drugs share a target with Ethotoin, and which of those have an active Phase 3 trial?
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