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Amobarbital
go.drugbank.com/drugs/DB01351ApprovedIllicitAdverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565) … A barbiturate with hypnotic and sedative properties (but not antianxiety).
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersSynonyms: 5-ethyl-5-(3-methylbutyl)barbituric acid, 5-ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrioneRurioctocog alfa pegol
go.drugbank.com/drugs/DB16007ApprovedInvestigational[L40119] Rurioctocog alfa pegol is a covalent conjugate of [octocog alfa], which is a recombinant factor VIII produced by recombinant DNA technology from a Chinese hamster ovary cell line. … Bleeding in joints is a common manifestation of hemophilia A, and bleeding episodes can be severe and life-threatening like intracranial hemorrhage.
Synonyms: Antihemophilic factor (recombinant), pegylated (20 kda), Antihemophilic factor (recombinant), pegylated (mw 20000)Tienilic acid
go.drugbank.com/drugs/DB04831ApprovedWithdrawnIt was withdrawn in 1982 after case reports in the United States suggested a link between ticrynafen and hepatitis. (Manier et al., 1982) … Tienilic acid, or ticrynafen, is a diuretic drug with uric acid-lowering action which was marketed for the treatment of hypertension.
Synonyms: (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid, 4-(2-Theonyl)-2,3-dichlorphenoxyessigsäureCategories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme InhibitorsMM-111
go.drugbank.com/drugs/DB17983InvestigationalMM-111 is a novel bispecific antibody fusion protein that co-targets the the epidermal growth factor family receptor tyrosine kinases, ERBB2 and ERBB3.
VAD-044
go.drugbank.com/drugs/DB17697InvestigationalVAD-044 is an allosteric AKT inhibitor developed by Vaderis Therapeutics AG. It is being investigated for the treatment of Hereditary Hemorrhagic Telangiectasia.[L46098]
Synonyms: 6-(4-((1S,3S)-1-amino-3-hydroxycyclobutyl)phenyl)-1-ethyl-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-oneLetibotulinumtoxinA
go.drugbank.com/drugs/DB16820Approved[L42330] It is a 900 kDa multimeric complex comprising a 150 kDa toxin, a 130 kDa non-toxic non-haemagglutinating protein, and various other haemagglutinins. … [A249920] LetibotulinumtoxinA is a type A botulinum neurotoxin produced from fermentation of _Clostridium botulinum_ strain CBFC26.
Categories: Botulinum Toxins, Type ASynonyms: BoNT/A-DSPaltimatrectinib
go.drugbank.com/drugs/DB21588InvestigationalPaltimatrectinib is under investigation in clinical trial NCT04901806 (Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors). … Paltimatrectinib is a small molecule drug. The usage of the INN stem '-trectinib' in the name indicates that Paltimatrectinib is a tropomyosin receptor kinase (TRK) inhibitor.
Resolvin E1
go.drugbank.com/drugs/DB13105InvestigationalResolvin E1 (RX 10001) is under investigation in clinical trial NCT00941018 (Single and Multiple Ascending Oral Dose Study of Resolvin E1 in Healthy Volunteers).
Categories: Fatty Acids, Omega-3Difelikefalin
go.drugbank.com/drugs/DB11938ApprovedInvestigationalPruritus associated with chronic kidney disease (also called uremic pruritus) affects 50-60% of all patients on dialysis and 25% of non-dialysis patients with chronic kidney disease. … [L36420,L36395] Difelikefalin was later approved by the EMA in April 2022 for the same indication.[L41665]
Categories: Heterocyclic Compounds, 1-RingTemelimab
go.drugbank.com/drugs/DB15634InvestigationalTemelimab is under investigation in clinical trial NCT02782858 (Clinical Trial Assessing the HERV-W Env Antagonist Gnbac1 for Efficacy in MS).
Categories: Recombinant Humanized IgG4 Monoclonal Antibody Against pHERV-W Envelope Protein