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Displaying results 2671 - 2680 of 10000 in total
  1. Drug

    Segesterone acetate

    go.drugbank.com/drugs/DB14583
    Approved

    Segesterone acetate is a steroidal progestin or synthetic progesterone and a 19-norprogesterone derivative with no CH3 group radical in position 6 [A37048]. … In clinical trials, Annovera™ achieved a 97.3% success in pregnancy prevention [L4246]. Annovera™ is administered as a vaginal ring that is in place for 21 days and removed for 7 days each cycle.

    Synonyms: 16-Methylene-17-alpha-acetoxy-19-nor-4-pregnene-3,20-dione, 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  2. Drug

    Dacomitinib

    go.drugbank.com/drugs/DB11963
    ApprovedInvestigational

    Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index
  3. Drug

    Ribavirin

    go.drugbank.com/drugs/DB00811
    ApprovedInvestigational

    Producing a broad-spectrum activity against several RNA and DNA viruses, Ribavirin is a synthetic guanosine nucleoside and antiviral agent that interferes with the synthesis of viral mRNA. … The potential use of ribavirin as a treatment for acute myeloid leukemia is currently under investigation.

    Mixtures: Rebetron Solution (albumin (human) Free) (18 Miu Multi-dose Pen / 200mg Capsules)Categories: Treatments for Hepatitis C
  4. Drug

    Xylometazoline

    go.drugbank.com/drugs/DB06694
    Approved

    Xylometazoline works by binding to alpha (α)-adrenergic receptors to cause vasoconstriction of nasal blood vessels.

    Mixtures: Ophtrivin A Ophthalmic Dps, nasic pur NasensprayCategories: Adrenergic alpha-1 Receptor Agonists, Heterocyclic Compounds, 1-Ring
  5. Drug

    DiaPep 277

    go.drugbank.com/drugs/DB06651
    Investigational

    DiaPep 277 is a 24-mer laboratory-made peptide derived from Hsp60(437-460).

    Categories: Group I Chaperonins, Diabetes Mellitus, Type 1
  6. Drug

    ISTH0036

    go.drugbank.com/drugs/DB18606
    Investigational

    ISTH0036 is a synthetic 14-mer phosphorothioate antisense oligonucleotide directed against TGF-beta2 mRNA

  7. Drug

    Estradiol cypionate

    go.drugbank.com/drugs/DB13954
    ApprovedVet approved

    As a pro-drug of estradiol, estradiol cypionate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and ERβ subtypes, which are located … Estradiol Cypionate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously within the human body.

    Mixtures: FEMELIN®, FEMELIN®Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  8. Drug

    Hydrocortisone acetate

    go.drugbank.com/drugs/DB14539
    ApprovedInvestigationalVet approved

    Mixtures: Actinac Pwr, Alcortin ACategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Inducers
  9. Drug

    Vildagliptin

    go.drugbank.com/drugs/DB04876
    ApprovedInvestigational

    , or a thiazolidinedione in patients with inadequate glycemic control following monotherapy. … Elevated levels of GLP-1 and GIP consequently results in improved glycemic control.[L32803] In clinical trials, vildagliptin has a relatively low risk of hypoglycemia.

    Mixtures: Vildagliptin/Metformin 1A Pharma 50 mg/850 mg – Filmtabletten, Vildagliptin/Metformin 1A Pharma 50 mg/1000 mg - FilmtablettenCategories: Glucagon-Like Peptide 1, P-glycoprotein substrates
  10. Drug

    Cocaine

    go.drugbank.com/drugs/DB00907
    ApprovedIllicitInvestigational

    It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. … It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: L-Cocain, L-Cocaine