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Pemetrexed
go.drugbank.com/drugs/DB00642ApprovedInvestigationalPemetrexed was first approved by the FDA in February 4, 2004.[A253907] … Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: PEMTREX 100 MG IV INF. ICIN LIYOFILIZE TOZ ICEREN FLAKON, 1 ADET, ALIMTA INFUZYON COZELTISI ICIN TOZ ICEREN FLAKON 10 ML, 1 ADETTrastuzumab
go.drugbank.com/drugs/DB00072ApprovedInvestigationalIt is suggested that the overexpression or gene amplification of HER2 has been found in about 20–30% of breast cancers and elevated activation of HER2 triggers multiple downstream pathways leading to abnormal … Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody [A40276] that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular
Mixtures: PHESGO® 1200 MG/600 MG, PHESGO® 1200 MG/600 MGProducts: KADCYLA (160 MG), HERCEPTIN 150 MG İNFÜZYONLUK ÇÖZELTİ İÇİN KONSANTRE TOZPseudoephedrine
go.drugbank.com/drugs/DB00852ApprovedPseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.
Mixtures: BENICAL 10 MG+20MG+2MG/5 ML SURUP, 100 ML, COLDFEN 100 MG+15 MG+1 MG/5 ML ŞURUP, 100 MLCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeNetilmicin
go.drugbank.com/drugs/DB00955ApprovedNetilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. … Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and interfering with mRNA binding and the acceptor tRNA site.
Mixtures: NETİZON 5 MG+15 MG/5 ML GÖZ DAMLASI, ÇÖZELTİ, 1 ADET, NETILDEX GOZ DAMLASI %0,1 DEKSAMETAZON + %0,3 NETILMISIN 5 MLProducts: NELIN 100 MG / 2ML INJECTION, NELIN 150 MG/ 1.5 ML INJECTIONNintedanib
go.drugbank.com/drugs/DB09079ApprovedInvestigationalbeing [Pirfenidone]) and as such is used as a first-line treatment following diagnosis to slow down the progressive loss of lung function. … [L8453] Within the spectrum of idiopathic pulmonary fibrosis treatment options, nintedanib is currently one of only two disease-modifying therapies available and indicated for the condition (the other
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Nintedanib Capsules, 100 mg and 150 mg, OFEV 100 MG YUMUSAK KAPSUL, 60 ADETPemlimogene merolisbac
go.drugbank.com/drugs/DB16286InvestigationalPemlimogene merolisbac is under investigation in clinical trial NCT03371381 (An Efficacy and Safety Study of JNJ-64041757, a Live Attenuated Listeria Monocytogenes Immunotherapy, in Combination With Nivolumab Versus Nivolumab Monotherapy...
Synonyms: Recombinant live-attenuated double-deleted (ladd) strain of listeria monocytogenes (lm .delta.acta/.delta.inlb) expressing a fusion protein comprising the n-terminal 100 amino acids of the lm acta protein, (actan100), 5 tandem copies of a 21 amino acid frDoxepin
go.drugbank.com/drugs/DB01142ApprovedInvestigational[T559] It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. … [T83] In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Serotonin 5-HT1 Receptor AntagonistsProducts: Rho-doxepin-10 Mg Cap, APO-DOXEPIN CAPSULE 10 mgIndomethacin
go.drugbank.com/drugs/DB00328ApprovedInvestigationalIntravenous indometacin is administered to close a hemodynamically significant patent ductus arteriosus, as indicated by clinical evidence, in premature infants. … [A177871] The pharmacological effect of indometacin is not fully understood, however, it is thought to be mediated through potent and nonselective inhibition of the enzyme cyclooxygenase (COX), which is
Mixtures: INDOBIOTIC GOZ DAMLASI, 5 MLCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesMiglitol
go.drugbank.com/drugs/DB00491Approvedmonosaccharides which can be absorbed by the body. … Unlike other drugs of the same class, miglitol is not metabolized and the unmetabolized drug is excreted by the kidneys.
Mixtures: MEGLITIS 100/500MG EFERVESAN TABLET, 100 TABLET, MEGLITIS 100/850MG EFERVESAN TABLET, 100 TABLETProducts: MIOL 50 MG TABLET ,100 TABLET, MIGLITEC 50 MG TABLET, 100 ADETTemozolomide
go.drugbank.com/drugs/DB00853ApprovedInvestigational[A229853, A229923] Temozomolide as an adjunct to radiotherapy followed by maintenance dosing remains the standard of care for both Glioblastoma and refractory anaplastic astrocytoma. … Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alkylating agents, although they invariably develop resistance to
Products: GLIOTEM 100 CAPSULE 100 MG, TEMOMID 100 MG KAPSUL, 5 ADET