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Estramustine
go.drugbank.com/drugs/DB01196ApprovedWithdrawnA nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Synonyms: Estradiol 3-(N,N-bis(2-chloroethyl)carbamate), 17β-Estradiol 3-(bis(2-chloroethyl)carbamate)Categories: Antineoplastic and Immunomodulating Agents, Cytochrome P-450 SubstratesSodium zirconium cyclosilicate
go.drugbank.com/drugs/DB14048ApprovedInvestigational[L2933] Approval of the medication is supported by data from three double-blind, placebo-controlled trials and two open-label trials which showed that the onset of action was approximately 1.0 hour and … [L2933] The treatment effect was maintained for up to 12 months.[L2933]
Categories: Drugs for Treatment of Hyperkalemia and Hyperphosphatemia, Compounds used in a research, industrial, or household settingProducts: SIMKELMA 5 G ORAL SÜSPANSİYON HAZIRLAMAK İÇİN TOZ, 11 ADET, SIMKELMA 10 G ORAL SÜSPANSİYON HAZIRLAMAK İÇİN TOZ, 11 ADETCarbimazole
go.drugbank.com/drugs/DB00389ApprovedAn imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.
Categories: Heterocyclic Compounds, 1-Ring, Sex Hormones and InsulinsSynonyms: Ethyl 3-methyl-2-thioimidazoline-1-carboxylateLovastatin
go.drugbank.com/drugs/DB00227ApprovedInvestigational[A181087, A181406] Evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within 5 years) statins cause a 20%-22% relative reduction in major cardiovascular … [A174553] More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid
Synonyms: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate, 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactoneCategories: lovastatin and nicotinic acid, Cytochrome P-450 SubstratesOlpasiran
go.drugbank.com/drugs/DB19001InvestigationalOlpasiran is under investigation in clinical trial NCT05581303 (Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (Ocean(a)) - Outcomes Trial).
Synonyms: -D-GALACTOPYRANOSYL)OXY)ETHOXY)ETHYL)CARBAMOYL)-1,23,28,33-TETRAOXO-1-SULFANYL-2,5,8,11,14,17,20,37-OCTAOXA-24,29,34-TRIAZA-1.L, ALL-P-AMBO-5'-O-((25S,30S)-39-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-25,30-BIS((2-(2-((2-ACETAMIDO-2-DEOXY-.BETA.Categories: Nucleic Acids, Nucleotides, and NucleosidesCefetamet pivoxil
go.drugbank.com/drugs/DB18915InvestigationalCefetamet pivoxil is under investigation in clinical trial NCT04664803 (Safety and Efficacy of Cefecin Tab. in Patients With Acute Sinusitis).
Synonyms: 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-methyl-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6r-(6.alpha.,7.beta.(z)))-Categories: Heterocyclic Compounds, 2-RingEsomeprazole
go.drugbank.com/drugs/DB00736ApprovedInvestigationalEsomeprazole is the s-isomer of [DB00338], which is a racemate of the S- and R-enantiomer. … [A177571] Rapid discontinuation of PPIs such as esomeprazole may cause a rebound effect and a short term increase in hypersecretion.
Mixtures: OCAM PROTECT 15 MG, OCAM PROTECT ® 15 MG TABLETAS DE LIBERACION RETARDADACategories: Heterocyclic Compounds, 1-Ring, Alimentary Tract and MetabolismAlfacalcidol
go.drugbank.com/drugs/DB01436ApprovedInvestigationalNutraceuticalAlfacalcidol, or 1-alpha-hydroxycholecalciferol or 1-alpha-hydroxyvitamin D3, is a non-endogenous analogue of [vitamin D]. … vitamin D resistant rickets and osteomalacia.
Synonyms: (5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1α,3β-diol, 1-hydroxycholecalciferolCategories: Vitamin D and Analogues, Alimentary Tract and MetabolismBurosumab
go.drugbank.com/drugs/DB14012ApprovedInvestigationalThis is the first drug approved to treat adults and children ages 1 year and older with X-linked hypophosphatemia (XLH), which is a rare, inherited form of rickets. … It causes impaired bone growth and development in children and adolescents and issues with bone mineralization throughout a patient’s life [L2346].
Categories: Amino Acids, Peptides, and Proteins, Drugs Affecting Bone Structure and MineralizationProducts: CRYSVITA® SOLUTION FOR INJECTION 10 MG/ML, CRYSVITA 10 MG SOLUTION FOR INJECTIONTopiramate
go.drugbank.com/drugs/DB00273ApprovedInvestigational[L10550] Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. … Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines.[A175249] It was initially approved by the FDA in 1996.
Mixtures: Phentermine and topiramate, Phentermine and topiramateCategories: Alimentary Tract and Metabolism, phentermine and topiramate