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Displaying results 2711 - 2720 of 10000 in total
  1. Drug

    Sunvozertinib

    go.drugbank.com/drugs/DB18925
    Investigational

    [A274143] Sunvozertinib was granted accelerated approval in the US on July 2, 2025 for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor … [L53488] EGFR is a transmembrane protein with cytoplasmic kinase activity commonly expressed by non-small cell lung carcinomas (NSCLCs).

    Synonyms: 2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1- methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-, N-{5-[(4-{[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino}pyrimidin-2-yl)amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl}prop-2-enamideCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  2. Drug

    N-[2-({[amino(imino)methyl]amino}oxy)ethyl]-2-{6-chloro-3-[(2,2-difluoro-2-phenylethyl)amino]-2-fluorophenyl}acetamide

    go.drugbank.com/drugs/DB07946
    Experimental

    Synonyms: N-[2-({[amino(imino)methyl]amino}oxy)ethyl]-2-{6-chloro-3-[(2,2-difluoro-2-phenylethyl)amino]-2-fluorophenyl}acetamide
  3. Drug

    AT9283

    go.drugbank.com/drugs/DB05169
    Investigational

    AT9283 is an aurora Kinase inhibitor developed by Astex Therapeutics for the treatment of cancer. It was discovered and developed internally using Astex’s fragment-based drug discovery platform, Pyramid.

    Synonyms: 1-Cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-ureaCategories: Heterocyclic Compounds, 2-Ring
  4. Drug

    Rezatapopt

    go.drugbank.com/drugs/DB18980
    Investigational

    Rezatapopt is under investigation in clinical trial NCT04585750 (The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)).

    Synonyms: 4-[[3-[4-[[(3S,4R)-3-Fluoro-1-methyl-4-piperidinyl]amino]-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl]-2-propyn-1-yl]amino]-3-methoxy-N-methylbenzamide, Benzamide, 4-[[3-[4-[[(3S,4R)-3-fluoro-1-methyl-4-piperidinyl]amino]-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl]-2-propyn-1-yl]amino]-3-methoxy-N-methyl-
  5. Drug

    Lucanthone

    go.drugbank.com/drugs/DB04967
    Investigational

    It is currently being tested as a radiation sensitizer.

    Synonyms: 1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one, 1-{[2-(diethylamino)ethyl]amino}-4-methylthioxanthen-9-oneInternational brands: Miracil D
  6. Drug

    Perospirone

    go.drugbank.com/drugs/DB08922
    Investigational

    Classified as a neuroleptic agent, perospirone is shown to be effective against positive, negative and general symptoms in patients with schizophrenia [A19676]. … It also displays affinity towards 5HT1A receptors as a partial agonist.

    Synonyms: cis-N-(4-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)butyl)-1,2-cyclohexanedicarboximideCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring
  7. Drug

    FG-2216

    go.drugbank.com/drugs/DB08687
    Investigational

    A orally active prolyl-hydroxylase inhibitor which can stabilize hypoxia-inducible transcription factor independent of oxygen availability. [A14422]

    Synonyms: (((1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl)amino)acetic acid, 1-Chloro-N- (hydroxyformylmethyl-4-hydroxyisoquinoline-3-carboxamide
  8. Drug

    Bunamidine

    go.drugbank.com/drugs/DB11501
    ExperimentalVet approved

    Bunamidine is a veterinary anti-platyhelmintic agent used for taenia infestations.

    Synonyms: N,N-Dibutyl-4-hexyloxy-1-naphthamidin, N,N-Dibutyl-4-(hexyloxy)-1-naphthamidine
  9. Drug

    Coumarin 120

    go.drugbank.com/drugs/DB08168
    Experimental

    Synonyms: 7-Amino-4-methylcoumarinCategories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-Ring
  10. Drug

    Kynurenine

    go.drugbank.com/drugs/DB02070
    Investigational

    Synonyms: (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 3-Anthraniloyl-L-alanine