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Rezatapopt

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Data Packages
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Identification

Generic Name
Rezatapopt
DrugBank Accession Number
DB18980
Background

Rezatapopt is under investigation in clinical trial NCT04585750 (The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 545.583
Monoisotopic: 545.24138791
Chemical Formula
C28H31F4N5O2
Synonyms
  • 4-[[3-[4-[[(3S,4R)-3-Fluoro-1-methyl-4-piperidinyl]amino]-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl]-2-propyn-1-yl]amino]-3-methoxy-N-methylbenzamide
  • Benzamide, 4-[[3-[4-[[(3S,4R)-3-fluoro-1-methyl-4-piperidinyl]amino]-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl]-2-propyn-1-yl]amino]-3-methoxy-N-methyl-
  • Rezatapopt
External IDs
  • PC 14586
  • PC-14586
  • PC14586
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
5W59S33KC9
CAS number
2636846-41-6
InChI Key
NKRKBSQLUPEVCZ-JTHBVZDNSA-N
InChI
InChI=1S/C28H31F4N5O2/c1-33-27(38)18-9-10-24(26(14-18)39-3)34-12-5-6-19-15-20-22(35-23-11-13-36(2)16-21(23)29)7-4-8-25(20)37(19)17-28(30,31)32/h4,7-10,14-15,21,23,34-35H,11-13,16-17H2,1-3H3,(H,33,38)/t21-,23-/m1/s1
IUPAC Name
SMILES
CNC(=O)C1=CC=C(NCC#CC2=CC3=C(N[C@@H]4CCN(C)C[C@@H]4F)C=CC=C3N2CC(F)(F)F)C(OC)=C1

References

General References
Not Available
ChemSpider
129309153

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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1, 2RecruitingTreatmentAdvanced Malignant Neoplasm / Advanced Solid Tumors / Breast Cancer / Colorectal Cancer / Endometrial Cancer / Head And Neck Cancer / Locally Advanced / Lung Cancer / Metastatic Cancer / Metastatic Solid Neoplasm / Other Cancers / Ovarian Cancer / Prostate Cancer1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at June 27, 2024 21:14 / Updated at June 28, 2024 04:47