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Displaying results 2711 - 2720 of 10000 in total
  1. Drug

    Lincomycin

    go.drugbank.com/drugs/DB01627
    ApprovedInvestigationalVet approved

    [A190621] Clinical use of lincomycin has largely been superseded by its semisynthetic derivative [clindamycin] due to its higher efficacy and a wider range of susceptible organisms, though lincomycin remains … Lincomycin is a lincosamide antibiotic first isolated from the soil bacterium _Streptomyces lincolnensis_ in Lincoln, Nebraska.

    Categories: Heterocyclic Compounds, 1-Ring, Macrolides, Lincosamides and StreptograminsProducts: LINKOLES 300 MG/ML KONSANTRE ÇÖZELTİ İÇEREN AMPUL, 5 ADET, LINCOCIN 2 ML 600 MG 1 AMPUL
  2. Drug

    Cefetamet pivoxil

    go.drugbank.com/drugs/DB18915
    Investigational

    Cefetamet pivoxil is under investigation in clinical trial NCT04664803 (Safety and Efficacy of Cefecin Tab. in Patients With Acute Sinusitis).

    Synonyms: 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-methyl-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6r-(6.alpha.,7.beta.(z)))-Categories: Heterocyclic Compounds, 2-Ring
  3. Drug

    Carbimazole

    go.drugbank.com/drugs/DB00389
    Approved

    An imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.

    Synonyms: Ethyl 3-methyl-2-thioimidazoline-1-carboxylateCategories: Heterocyclic Compounds, 1-Ring, Sex Hormones and Insulins
  4. Drug

    Flecainide

    go.drugbank.com/drugs/DB01195
    ApprovedInvestigationalWithdrawn

    Flecainide is a Class I anti-arrhythmic agent like [encainide] and [propafenone]. … [A186931] It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.

    Synonyms: N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamideCategories: MATE 1 Inhibitors, MATE 1 Substrates
  5. Drug

    Rocbrutinib

    go.drugbank.com/drugs/DB19445
    Investigational

    Rocbrutinib is under investigation in clinical trial NCT05716087 (A Study of Rocbrutinib in Participants With Relapse or Refractory Mantle Cell Lymphoma).

    Synonyms: 2-Propenamide, N-[5-[[6-[2-(1,3,4,6,7,8-hexahydro-7,7-dimethyl-1-oxo-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3-(hydroxymethyl)-4-pyridinyl]-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl]amino]-2-[(2S)-2, N-[5-[[6-[2-(1,3,4,6,7,8-Hexahydro-7,7-dimethyl-1-oxo-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3-(hydroxymethyl)-4-pyridinyl]-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl]amino]-2-[(2S)-2-methyl-4-(tetrahydro
  6. Drug

    Burosumab

    go.drugbank.com/drugs/DB14012
    ApprovedInvestigational

    This is the first drug approved to treat adults and children ages 1 year and older with X-linked hypophosphatemia (XLH), which is a rare, inherited form of rickets. … It causes impaired bone growth and development in children and adolescents and issues with bone mineralization throughout a patient’s life [L2346].

    Categories: Amino Acids, Peptides, and Proteins, Drugs Affecting Bone Structure and MineralizationProducts: CRYSVITA® SOLUTION FOR INJECTION 10 MG/ML, CRYSVITA 10 MG SOLUTION FOR INJECTION
  7. Drug

    D3S-001

    go.drugbank.com/drugs/DB19008
    Investigational

    D3S-001 is under investigation in clinical trial NCT05410145 (A Study of D3S 001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.g12c Mutation).

    Synonyms: 2-PIPERAZINEACETONITRILE, 4-(7-(3-AMINO-2-FLUORO-5-METHYL-6-(TRIFLUOROMETHYL)PHENYL)-2-(((2R,7AS)-2-FLUOROTETRAHYDRO-1H-PYRROLIZIN-7A(5H)-YL)METHOXY)-7,8-DIHYDRO-5H-PYRANO(4,3-D)PYRIMIDIN-4-YL)-1-(2-FLUORO, -1-OXO-2-PROPEN-1-YL)-, (2S)-
  8. Drug

    Granaticin B

    go.drugbank.com/drugs/DB17273
    Investigational

    Synonyms: 8,11-ethanofuro(2,3-e)naphtho(2,3-c:6,7-c')dipyran-2,6,13(9h)-trione, 3,3a,5,8,11,13b-hexahydro-7,8,12-trihydroxy-5,9-dimethyl-15-(((2s,5s,6s)-tetrahydro-5-hydroxy-6-methyl-2h-pyran-2-yl)oxy)-, (3as,5s, Granaticin BCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  9. Drug

    Pemrametostat

    go.drugbank.com/drugs/DB19170
    Investigational

    Pemrametostat is under investigation in clinical trial NCT03614728 (Study to Investigate the Safety and Clinical Activity of GSK3326595 and Other Agents to Treat Myelodysplastic Syndrome (MDS) and Acute

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: Protein arginine methyltransferase 5 inhibitor gsk3326595, 4-pyrimidinecarboxamide, 6-((1-acetyl-4-piperidinyl)amino)-n-((2s)-3-(3,4-dihydro-2(1h)-isoquinolinyl)-2-hydroxypropyl)-
  10. Drug

    Lovastatin

    go.drugbank.com/drugs/DB00227
    ApprovedInvestigational

    [A181087, A181406] Evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within 5 years) statins cause a 20%-22% relative reduction in major cardiovascular … [A174553] More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid

    Synonyms: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate, 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactoneCategories: lovastatin and nicotinic acid, Cytochrome P-450 Substrates