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Bexagliflozin
go.drugbank.com/drugs/DB12236ApprovedInvestigational[A256408] By inhibiting SGLT2, bexagliflozin reduces renal reabsorption of filtered glucose and increases urinary glucose excretion, which reduces blood glucose levels independently of insulin sensitivity … Bexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor.
Categories: Alimentary Tract and MetabolismPhenylpropanolamine
go.drugbank.com/drugs/DB00397ApprovedVet approvedWithdrawnIt has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. … Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor.
Mixtures: Counteract Sinus and Allergy, Contac Cough Cold and Flu CapletsGlycerol phenylbutyrate
go.drugbank.com/drugs/DB08909ApprovedInvestigationalGlycerol phenylbutyrate is a nitrogen-binding agent. Chemically, it is a triglyceride in which three molecules of phenylbutyrate are linked to a glycerol backbone. FDA approved on February 1, 2013.
Categories: Alimentary Tract and Metabolism, Various Alimentary Tract and Metabolism ProductsButamben
go.drugbank.com/drugs/DB11148ApprovedWithdrawn[A27147] Its structure corresponds to the standard molecule of a hydrophilic and hydrophobic domain separated by an intermediate ester found in most of the local anesthetics. … The FDA removed all parenteral butamben products from the market, possibly due to the poor solubility of this drug.[A254247,L43942]
Denileukin diftitox
go.drugbank.com/drugs/DB00004ApprovedInvestigational[A264344] In 2014, it was withdrawn voluntarily from the market due to manufacturing issues; however, the biologics license application (BLA) for denileukin diftitox was resubmitted, and it was approved … approved to treat a human disease in the US.
Categories: Enzymes and Coenzymes, Amino Acids, Peptides, and ProteinsThioredoxin reductase
go.drugbank.com/bio_entities/BE0010144TargetMousePromotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components. … Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation.
Synonyms: Thioredoxin and glutathione reductaseCefonicid
go.drugbank.com/drugs/DB01328ApprovedIts bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
Rilonacept
go.drugbank.com/drugs/DB06372ApprovedInvestigationaland Muckle-Wells Syndrome (MWS), in adults and children greater than 12 years old. … Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold auto-inflammatory syndrome (FCAS)
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsDoxercalciferol
go.drugbank.com/drugs/DB06410ApprovedInvestigationalDoxercalciferol is marketed under the brand name Hectoral by Genzyme Corporation, and is manufactured by Catalent Pharma Solutions, Inc. … Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin
Categories: Diet, Food, and Nutrition, Vitamin D and AnaloguesVelpatasvir
go.drugbank.com/drugs/DB11613ApprovedInvestigationalVelpatasvir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). … , and reduced all-cause mortality and risk of requiring a liver transplant [A19626].
Mixtures: Sofosbuvir and Velpatasvir, EPCLUSA TABLET 400MG/100MGCategories: sofosbuvir and velpatasvir, sofosbuvir, velpatasvir and voxilaprevir