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Atezolizumab
go.drugbank.com/drugs/DB11595ApprovedInvestigationalAtezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers. … [A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy.
Categories: PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsProducts: Tecentriq Sc, TECENTRIQ SCAcetic acid
go.drugbank.com/drugs/DB03166ApprovedInvestigationalAcetic acid is a product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. … (Stedman, 26th ed) Acetic acid otic (for the ear) is an antibiotic that treats infections caused by bacteria or fungus.
Mixtures: POLYLAB T-EUSOL (SOLUTION A & B), POLYLAB T-EUSOL( SOLUTION A & B)Categories: Compounds used in a research, industrial, or household settingDostarlimab
go.drugbank.com/drugs/DB15627ApprovedInvestigationalDostarlimab is an IgG<sub>4</sub> humanized monoclonal antibody targeted against the human programmed death receptor-1 (PD-1). … [L33320] PD-1 receptors are found on T-cells and, when activated, serve to inhibit immune responses - some cancers leverage this system by overexpressing PD-1 ligands, thereby effectively inhibiting the
Categories: PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsSynonyms: Immunoglobulin G4, anti-programmed cell death protein 1 (PDCD1) (humanized clone ABT1 gamma4-chain), disulfide with humanized clone ABT1 kappa-chain, dimerAzatadine
go.drugbank.com/drugs/DB00719ApprovedWithdrawnAntihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. … The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury
Mixtures: X-TRI D, XL-3 VRCategories: Heterocyclic Compounds, 1-RingAntazoline
go.drugbank.com/drugs/DB08799ApprovedIt is also formulated as eye drops with naphazoline to relieve allergic conjunctivitis. … Antazoline is a 1st generation antihistamine with anticholinergic activity. It is used to relieve nasal congestion.
Mixtures: Albalon A, Zincfrin ACategories: Heterocyclic Compounds, 1-RingErythrityl tetranitrate
go.drugbank.com/drugs/DB01613ApprovedWithdrawnA vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)
Synonyms: Tetranitrato de eritritilo, (2R*,3S)-rel-1,2,3,4-butanetetroltetranitrateDamoctocog alfa pegol
go.drugbank.com/drugs/DB14700ApprovedInvestigational[A38907] Also known as, BAY94-9027, Damoctocog alfa pegol is a longer-acting Factor VIII therapy formulated with polyethylene glycol (PEG) to reduce the number of infusions necessary to prevent bleeds … In order to extend half-lives, techniques such as fusion to protein conjugates (Fc part of IgG1 or albumin), chemical modification (PEGylation), and protein sequence modification have been utilized.
Piritramide
go.drugbank.com/drugs/DB12492ApprovedWithdrawnPiritramide is under investigation for the treatment of Colon Cancer and Minimal Residual Disease. … Piritramide has been investigated for the supportive care of Pain, Postoperative and Postoperative Nausea and Vomiting.
Categories: Heterocyclic Compounds, 1-Ring, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeAsunaprevir
go.drugbank.com/drugs/DB11586ApprovedWithdrawnIt has been shown to have a very high efficacy in dual-combination regimens with daclatasvir in patients chronically infected with HCV genotype 1b. … The commercialization of asunaprevir was cancelled one year later on October 16, 2017.[L1113]
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: SUNVEPRA® 100MG CÁPSULAS BLANDASCopper histidinate
go.drugbank.com/drugs/DB32041ApprovedMenkes disease is a rare, X-linked recessive disorder caused by pathogenic variants in the ATP7A gene, which encodes a copper transport protein essential for absorbing dietary copper and transporting it … [A275383,T903] In patients with the disease, defects in this transporter lead to the entrapment of copper in the intestinal lining and a subsequent inability to absorb it into the bloodstream, resulting