A vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020).
- Mechanism
- Curator reviewed
Similar to other nitrites and organic nitrates, erythrityl tetranitrate is converted to an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
- Primary indication
- For the prevention of angina.Curator reviewed
- Formula / weight
- C4H6N4O12 · 302.11 g/mol (avg)
- Also known as
- Eritrityl tetranitrate · Erythritol tetranitrate · Erythrol tetranitrate · Meso-erythritol tetranitrate · Tetranitrin
- Code names
- NSC-106566
Resolves to
SNFOERUNNSHUGP-ZXZARUISSA-NSMILES[O-][N+](=O)OC[C@@H](O[N+]([O-])=O)[C@H](CO[N+]([O-])=O)O[N+]([O-])=OWhat you can answer from here — as of September 16, 2026
Which drugs share a target with Erythrityl tetranitrate, and which of those have an active Phase 3 trial?
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