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Emicizumab
go.drugbank.com/drugs/DB13923ApprovedInvestigationalEmicizumab was originated as an improved form of hBS23 and it was approved on November 16, 2017.[A31279, L1016] It was created by Chugai Pharmaceuticals Co. … Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation Factor VIII and it has the capacity to bind simultaneously to activated Factor IX and Factor X.
Products: HEMLIBRA® 150 MG/ML SOLUCIÓN INYECTABLE, HEMLİBRA 150 MG/ 1 ML S.C. ENJEKSİYONLUK ÇÖZELTİ, 1 ADETAstemizole
go.drugbank.com/drugs/DB00637ApprovedWithdrawnIt was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. … Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms.
Categories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: ALMIZOL 10 MG TABLET, 10 ADET, ULKAMIZOL 10 MG TABLET, 10 ADETSibutramine
go.drugbank.com/drugs/DB01105ApprovedIllicitWithdrawnIn October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease. … It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the United States.
Mixtures: IFA CERTEZ DUOCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCorifollitropin alfa
go.drugbank.com/drugs/DB09066ApprovedInvestigationalMultiple studies and a meta-analysis suggest that corifollitropin alfa is as efficacious as recombinant FSH in terms of live birth rate, ongoing pregnancy rate, as well as clinical pregnancy rate. … Corifollitropin alfa, also known as _Elonva_ is used in women undergoing fertility treatment to stimulate the development of more than one mature egg (oocyte) at a time in the ovaries.
Products: ELONVA 150 MCG/0,5 ML ENJEKSIYONLUK COZELTI, 1 ADET, ELONVA 150 MCG/0,5 ML ENJEKSİYONLUK ÇÖZELTİ, 1 ADETEsmolol
go.drugbank.com/drugs/DB00187ApprovedInvestigationalWithdrawnThe FDA withdrew its approval for the use of all parenteral dosage form drug products containing esmolol hydrochloride that supply 250 milligrams/milliliter of concentrated esmolol per 10-milliliter ampule … It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesProducts: Brevibloc 100 mg/10 ml - Infusionslösung, Esmolol Amomed 100 mg/10 ml InfusionslösungEstriol
go.drugbank.com/drugs/DB04573ApprovedInvestigationalVet approvedA hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. … Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada.
Mixtures: GYNOFLOR 50 MG/0.03 MG VAJİNAL TABLET, 6 ADET, GYNOFLOR 50 MG/0.03 MG VAJİNAL TABLET, 12 ADETSynonyms: (16α,17β)-estra-1,3,5(10)-triene-3,16,17-triol, 1,3,5(10)-Estratriene-3,16-alpha,17beta-triolMebeverine
go.drugbank.com/drugs/DB12554ApprovedInvestigationalWithdrawnMebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.
Mixtures: ARLUY DUO, ARLUY-DUOProducts: DUSPATALIN LIKIT 10 MG/ML, 250 ML, DUSPATALIN CÁPSULA DE LIBERACIÓN PROLONGADA 200 MG.Ephedrine
go.drugbank.com/drugs/DB01364ApprovedInvestigational[A193698] Ephedrine acts as both a direct and indirect sympathomimetic. … [L12972] Ephedrine and [phenylephrine] are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists.
Mixtures: BROKSIN 6.66 MG/5 ML+100 MG/5 ML SURUP, 150 ML, OPSIS SURUP, 150 MLProducts: RINITALMIT LIQUIDE, 15 ML, Ephedrin Meduna 10 mg/ml InjektionslösungSulfasalazine
go.drugbank.com/drugs/DB00795ApprovedInvestigational[A255582] Sulfasalazine fell out of favor as the drug of choice for RA due to poorly designed clinical trials in 1950 but regained interest from the clinical community in the late 1970. … [A255582] Compared to the first line treatment of RA like methotrexate, sulfasalazine is almost as efficacious as methotrexate although with slightly less tolerability.
International brands: Saaz-DSProducts: Sas Tab 500mg, Sas Enema 3gm/100mlValsartan
go.drugbank.com/drugs/DB00177ApprovedInvestigational[A174124,A178153,A173869,A185324,A185327,A185333,A185342,A185345] Valsartan also slows the progression of diabetic nephropathy due to its renoprotective effects. … ARBs such as valsartan have been shown in a number of large-scale clinical outcomes trials to improve cardiovascular outcomes including reducing risk of myocardial infarction, stroke, the progression of
Mixtures: VALSARTAN COMP PU 160/12.5, VALSARTAN COMP PU 160/12.5Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Inhibitors