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Domperidone
go.drugbank.com/drugs/DB01184ApprovedInvestigationalVet approvedA specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Mixtures: LACOMBI 15/10 MG KAPSUL, 28 ADET, DUOLANS 15/30 MG SR KAPSUL, 28 ADETCategories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substratesCamsirubicin
go.drugbank.com/drugs/DB13103InvestigationalGPX-150 has been used in trials studying the treatment of Soft Tissue Sarcoma and Advanced Solid Tumors - Phase 1 Population.
Synonyms: 5(8H)-Naphthacenone, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,9,10,12-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyethyl)-12-imino-1-methoxy-, (8R,10S)-, 5-imino-13-deoxydoxorubicin5-Iodo-2'-Deoxyuridine-5'-Monophosphate
go.drugbank.com/drugs/DB02324ExperimentalSynonyms: 5-Iodo-2'-Deoxyuridine-5'-Monophosphate5'-deoxy-5'-piperidin-1-ylthymidine
go.drugbank.com/drugs/DB08596ExperimentalSynonyms: 5'-deoxy-5'-piperidin-1-ylthymidineLumiracoxib
go.drugbank.com/drugs/DB01283ApprovedWithdrawnOn August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in Australia due to concerns that it may cause liver … Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID).
Categories: COX-2 Inhibitors, Cytochrome P-450 SubstratesSynonyms: 2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acidRosuvastatin
go.drugbank.com/drugs/DB01098ApprovedInvestigational[A181087, A181406] Evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within 5 years) statins cause a 20%-22% relative reduction in major cardiovascular … More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid and is
Mixtures: LIPIVAN E ® 10 MG / 10 MG, Rosamib 5 mg/10 mg TablettenCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesPirtobrutinib
go.drugbank.com/drugs/DB17472ApprovedInvestigationalPirtobrutinib is a small molecule and a highly selective non-covalent inhibitor of Bruton’s tyrosine kinase (BTK). … Although the mechanisms of resistance to covalent BTK inhibitors have not been fully elucidated, it appears that the presence of Cys481 mutations is the most common reason for resistance to covalent BTK
Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein inhibitorsSynonyms: 1h-pyrazole-4-carboxamide, 5-amino-3-(4-(((5-fluoro-2-methoxybenzoyl)amino)methyl)phenyl)-1-((1s)-2,2,2-trifluoro-1-methylethyl)-, (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1h-pyrazole-4-carboxamideBrivudine
go.drugbank.com/drugs/DB03312ApprovedInvestigationalAlthough not approved in the U.S. or Canada, it is approved in several European countries.
Categories: Heterocyclic Compounds, 1-RingSynonyms: (E)-5-(2-Bromovinyl)-deoxyuridineLodoxamide
go.drugbank.com/drugs/DB06794ApprovedLodoxamide is a mast-cell stabilizer for topical administration into the eye. … Although less effective than topical steroids at decreasing inflammation, mast-cell stabilizers offer another treatment option and exhibit minimal adverse effects.
Synonyms: N,N'-(2-chloro-5-cyano-m-phenylene)dioxamateProducts: THILOMIDE GÖZ DAMLASI, 5 ML, ALOMİDE % 0.1 GÖZ DAMLASI, ÇÖZELTİ, 5 MLZafirlukast
go.drugbank.com/drugs/DB00549ApprovedIt is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), which is usually taken just once daily.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: 4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide, cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate