Domperidone is a dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. A specific blocker of dopamine receptors.
- Mechanism
- Curator reviewed
Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting
- Primary indication
- For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.Curator reviewed · 7 structured indications
- Formula / weight
- C22H24ClN5O2 · 425.911 g/mol (avg)
- First approval
- Canada, 1997
- Code names
- R-33812
Resolves to
FGXWKSZFVQUSTL-UHFFFAOYSA-NSMILESClC1=CC2=C(C=C1)N(C1CCN(CCCN3C(=O)NC4=CC=CC=C34)CC1)C(=O)N2What you can answer from here — as of September 19, 2026
Which drugs share a target with Domperidone, and which of those have an active Phase 3 trial?
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