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Displaying results 2891 - 2900 of 10000 in total
  1. Drug

    Histamine

    go.drugbank.com/drugs/DB05381
    ApprovedInvestigational

    It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. … A depressor amine derived by enzymatic decarboxylation of histidine.

    Mixtures: Histamine DHCl 0.10 Percent and Menthol 2 Percent, MIKES Ponos Pain Relief Cream Roll-OnCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A Inhibitors
  2. Drug

    Prazosin

    go.drugbank.com/drugs/DB00457
    ApprovedInvestigational

    Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. … [L5828] It belongs to the class of drugs known as alpha-1 antagonists.

    Categories: Heterocyclic Compounds, 2-Ring, P-glycoprotein inhibitorsSynonyms: 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine
  3. Drug

    Micafungin

    go.drugbank.com/drugs/DB01141
    ApprovedInvestigational

    It belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. … Micafungin is an antifungal drug.

    Products: Micafungin in Sodium Chloride, Micafungin In 0.9% Sodium Chloride Injection
  4. Drug

    Thiotepa

    go.drugbank.com/drugs/DB04572
    ApprovedInvestigational

    It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. … N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years.

    Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: N,N′,N′′-tri-1,2-ethanediyl-, Phosphorothioic triamide, N,N′,N′′-tri-1,2-ethanediyl-
  5. Drug

    Fluvoxamine

    go.drugbank.com/drugs/DB00176
    ApprovedInvestigational

    Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. … Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database comprised of approximately 35,000 patients.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: VERLIN TABLETAS X 50 MG, VOXAMIN® TABLETA RECUBIERTA
  6. Drug

    Cefotaxime

    go.drugbank.com/drugs/DB00493
    ApprovedInvestigational

    In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis). … Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria.

    Synonyms: (6R,7R,Z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid, (6R,7R)-3-(acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidMixtures: SEFOTAK 1 G IM ENJEKSİYONLUK TOZ İÇEREN FLAKON, 1 ADET
  7. Drug

    Des(carbamimidoyl) zanamivir

    go.drugbank.com/drugs/DB03321
    Experimental

    Synonyms: 4-AM-DANA, 4-Amino-2-deoxy-2,3-dehydro-N-neuraminic acid
  8. Drug

    Alitretinoin

    go.drugbank.com/drugs/DB00523
    Approved

    Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. … An important regulator of gene expression during growth and development, and in neoplasms.

    Mixtures: Clindamycin 1% / Niacinamide 4% / Tretinoin 0.05%Categories: Vitamin A, P-glycoprotein substrates
  9. Drug

    Canagliflozin

    go.drugbank.com/drugs/DB08907
    ApprovedInvestigational

    Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise … 2 diabetes mellitus [L5897], [FDA label].

    Mixtures: VOKANAMET ® TM_TABLETAS RECUBIERTAS 150/1000 MG, VOKANAMET 50 MG/500 MGCategories: Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors, Drugs Used in Diabetes
  10. Drug

    Avibactam

    go.drugbank.com/drugs/DB09060
    ApprovedInvestigational

    This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract … Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz).

    Mixtures: ZAVİCEFTA 2 G/0.5 G İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZ, 10 ADETProducts: ZAVICEFTA POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 2G/0.5G