Search
Alemtuzumab
go.drugbank.com/drugs/DB00087ApprovedInvestigational[L43397] It is marketed as LEMTRADA for multiple sclerosis (MS) treatment and CAMPTAH for B-cell chronic lymphocytic leukemia (B-CLL). … The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G).
Synonyms: Campath 1-HProducts: MABCAMPATH INF SOL ICIN 30 MG/ML KONS 1 ML 3 FLK (10 MG/ML KONSANTRE 3 AMP), MABCAMPATH ® 30 MG/MLTeriflunomide
go.drugbank.com/drugs/DB08880ApprovedInvestigationalIt is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. … Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis.
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersSynonyms: (Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidideEsomeprazole
go.drugbank.com/drugs/DB00736ApprovedInvestigationalEsomeprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme … [A177571] Rapid discontinuation of PPIs such as esomeprazole may cause a rebound effect and a short term increase in hypersecretion.
Synonyms: (S)-omeprazole, (S)-(−)-omeprazoleInternational brands: ES-ODCarmustine
go.drugbank.com/drugs/DB00262ApprovedInvestigational(From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). … (From Merck Index, 11th ed)
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: N,N'-Bis(2-chloroethyl)-N-nitrosoureaThiotepa
go.drugbank.com/drugs/DB04572ApprovedInvestigationalN,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. … It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer.
Synonyms: N,N′,N′′-tri-1,2-ethanediyl-, Phosphorothioic triamide, N,N′,N′′-tri-1,2-ethanediyl-Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesKetoconazole
go.drugbank.com/drugs/DB01026ApprovedInvestigationalKetoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections. … [A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981.
Mixtures: CLINDAMICINA/KETOCONAZOL 100 MG/400MG, Ketoconazole 2% / Niacinamide 4%Categories: P-glycoprotein inhibitors, P-glycoprotein substratesPergolide
go.drugbank.com/drugs/DB01186ApprovedVet approvedWithdrawnIt is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. … Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease.
Categories: Serotonin 5-HT2 Receptor Agonists, Adrenergic alpha-1 Receptor AgonistsProducts: PERGOLID-NEURAX 1 MG, PERGOLIDE EGPantothenic acid
go.drugbank.com/drugs/DB01783ApprovedInvestigationalNutraceuticalVet approvedPantothenic acid, also called pantothenate or vitamin B5 (a B vitamin), is a water-soluble vitamin discovered by Roger J. Williams in 1919. … Pantothenic acid is an ingredient in some hair and skin care products.
Mixtures: B Plus C 300 mg, Stress B With 1000 Mg Vitamin CCategories: Vitamin B ComplexGadobenic acid
go.drugbank.com/drugs/DB00743ApprovedInvestigationalGadobenic acid, usually available in the salt form gadobenate dimeglumine, is a linear MRI gadolinium-based contrast agent (GBCA) used primarily for MR imaging of the liver. … [A263166] As gadobenate dimeglumine is specifically taken up by hepatocytes and excreted through the biliary system, it is a useful contrast agent for liver MRI.
Mixtures: MULTIHANCE INJECTION 10 ML, MULTIHANCE INJECTION 10 MLCategories: Compounds used in a research, industrial, or household settingHydrocodone
go.drugbank.com/drugs/DB00956ApprovedIllicitInvestigationalHydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain. … Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by [dextromethorphan] in current cough and cold formulations.
Synonyms: 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-oneMixtures: DOXU ® 5/250 MG TABLETA RECUBIERTA, ACETAMINOFEN / HIDROCODONA BITARTRATO 325 MG / 5 MG TABLETAS