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Viltolarsen
go.drugbank.com/drugs/DB15005ApprovedInvestigationalAlthough corticosteroids are effective in slowing disease progression in both DMD and BMD patients, they do not address the underlying molecular pathogenesis. … A related, albeit a less severe, form of muscular dystrophy known as Becker muscular dystrophy (BMD) is characterized by the production of shortened and partially functional dystrophin protein.
Rexin G
go.drugbank.com/drugs/DB16450InvestigationalRexin-G is a tumor-targeted, injectable retroviral vector carrying a mutant form of the cyclin G1 gene.
Synonyms: DeltaRex-G Retroviral Vector Encoding a Cyclin G1 Inhibitor, Mx-dnG1International brands: Rexin-GLevobunolol
go.drugbank.com/drugs/DB01210ApprovedA nonselective beta-adrenoceptor antagonist used in the treatment of glaucoma.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesBulevirtide
go.drugbank.com/drugs/DB15248ApprovedInvestigational[A226305] Bulevirtide, also known as Hepcludex, is a first-in-class entry inhibitor for the treatment of chronic Hepatitis D infection developed by MYR Pharmaceuticals, now part of Gilead. … Hepatitis D is considered the most severe type of viral hepatitis and leads to the rapid development of cirrhosis, severe decompensation of liver function, and an increased risk of mortality.
Obeticholic acid
go.drugbank.com/drugs/DB05990ApprovedInvestigationalto a risk of liver failure, in some cases requiring liver transplantation. … , the FDA updated its prescribing information to contraindicate the use of obeticholic acid in patients with PBC and advanced cirrhosis (e.g. those with portal hypertension or hepatic decompensation) due
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsUprifosbuvir
go.drugbank.com/drugs/DB15206InvestigationalUprifosbuvir is under investigation in clinical trial NCT02332707 (Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis … C Genotype (GT)1 and GT2 Infection (MK-3682-011)).
Potassium hydroxide
go.drugbank.com/drugs/DB11153ApprovedPotassium hydroxide is also a precursor to other potassium compounds. Potassium hydroxide is used in food to adjust pH, as a stabilizer, and as a thickening agent. … Potassium hydroxide, also known as _lye_ is an inorganic compound with the chemical formula _KOH_.
Synonyms: hydroxyde de potassiumCategories: Compounds used in a research, industrial, or household settingMelphalan flufenamide
go.drugbank.com/drugs/DB16627ApprovedWithdrawn[A230123] _In vitro_ models show that melphalan is 10 to hundreds of times more potent than melphalan. … Melphalan flufenamide, also known as melflufen or J1, is a prodrug of [melphalan].
De Novo Triacylglycerol Biosynthesis TG(14:0/18:3(9Z,12Z,15Z)/15:0)
smpdb.ca/view/SMP0016762MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(15:0/14:0/18:3(9Z,12Z,15Z))
smpdb.ca/view/SMP0016943MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...