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Odronextamab
go.drugbank.com/drugs/DB16684ApprovedInvestigational[L43887,L43892] A phase I clinical study (NCT02290951) showed that in heavily pre-treated patients with B-cell non-Hodgkin lymphoma, odronextamab elicited a durable response with a manageable safety … of cytokine release syndrome (CRS), a serious condition associated with the use of immunotherapy.
Bedaquiline
go.drugbank.com/drugs/DB08903ApprovedInvestigationalBedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. … [A261861] Bedaquiline was approved by the FDA on December 28, 2012, to treat pulmonary MDR-TB, following favorable results in multiple pre-clinical and clinical studies.
Synonyms: 1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-olCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesXanomeline
go.drugbank.com/drugs/DB15357ApprovedInvestigational[A264509] Advances in pre-clinical research and findings in clinical trials have led to a resurgence of interest in the cognition-enhancing potential of muscarinic agonists in schizophrenia, as it was … Schizophrenia is a complex disease involving a number of different neurotransmitters, including serotonin, dopamine, and acetylcholine.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesRemdesivir
go.drugbank.com/drugs/DB14761ApprovedInvestigationalSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia … Like other RNA viruses, SARS-CoV-2 depends on an RNA-dependent RNA polymerase (RdRp) enzyme complex for genomic replication, which can be inhibited by a class of drugs known as nucleoside analogues.
Categories: MATE 1 Inhibitors, P-glycoprotein substratesProducts: VEKLURY® LYOPHILIZED POWDER FOR IV INFUSION 100MG/VIAL, VEKLURY 100 MG İNFÜZYONLUK ÇÖZELTİ KONSANTRESİ İÇİN TOZ, 1 ADETNateglinide
go.drugbank.com/drugs/DB00731ApprovedMeglitnides may have a neutral effect on weight or cause a slight increase in weight. … It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen.
Mixtures: NAT-ALA 120/200 MG FILM KAPLI TABLET, 90 ADET, NAT-ALA 180/200 MG FILM KAPLI TABLET, 90 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSulbactam
go.drugbank.com/drugs/DB09324ApprovedInvestigationalSulbactam is a beta (β)-lactamase inhibitor and a derivative of the basic penicillin nucleus. … [L50131] When given in combination with β-lactam antibiotics, sulbactam produces a synergistic effect as it blocks the enzyme responsible for drug resistance by hydrolyzing β-lactams.[A263296]
Synonyms: (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide, (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxideMixtures: AUROPENNZ 1.5 G POLVO ESTERIL PARA RECONSTITUIR A SOLUCION INYECTABLE, AMPICILLINA E SULBACTAM IBIBenzoic acid
go.drugbank.com/drugs/DB03793ApprovedInvestigationalA fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. … This leads to excretion of these amino acids and a decrease in ammonia levels. Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia.
Mixtures: CLISMA LAX, CLISMA LAXCategories: Compounds used in a research, industrial, or household settingVIT-100
go.drugbank.com/drugs/DB05865ExperimentalIn preclinical studies, companyl has shown that VIT-100 inhibits the growth of cells taken from multiple keloid biopsies as compared to the same keloidal cells treated with a control. … It is believed that similar effects would be seen in cells isolated from hypertrophic scars.
Fenretinide
go.drugbank.com/drugs/DB05076InvestigationalA synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.
Synonyms: 4-HPR, N-(4-hydroxyphenyl)all-trans retinamideCategories: Compounds used in a research, industrial, or household settingEnzalutamide
go.drugbank.com/drugs/DB08899ApprovedInvestigationalCompared to the average time of 10 to 15 years for a drug to go from pre-clinical to clinical studies, enzalutamide was developed relatively rapidly.[A252667] … [A252667,A252642] Due to a favorable pharmacological profile, a phase 1 study of enzalutamide was initiated in July 2007.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: Enzalutamid 1A Pharma 40 mg - Filmtabletten, Enzalutamid 1A Pharma 80 mg - Filmtabletten